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A Targeted Therapy for Myelofibrosis

Read below for Selected Safety Information. Hematologist-oncologist Gary Grad, MD explains how a targeted therapy called Jakafi® (ruxolitinib) acts in the body to help treat adults with intermediate- or high-risk myelofibrosis (MF). Jakafi is the first targeted therapy approved by the Food and Drug Administration for the treatment of these patients. Myelofibrosis is a rare, chronic blood cancer that is part of a group of diseases called myeloproliferative neoplasms (MPNs). This video is intended for informational use only, and is not designed to replace the medical advice of your Healthcare Professional. Jakafi used to treat adults with intermediate or high-risk myelofibrosis , including primary MF, post-polycythemia vera MF and post-essential thrombocythemia MF. Selected Safety Information Jakafi can cause serious side effects including low blood counts and infection. Some people who take Jakafi have developed certain types of non‐melanoma skin cancers. Increases in blood cholesterol levels can also occur. In patients who took another JAK inhibitor to treat rheumatoid arthritis, there was an increased risk of potentially fatal cardiovascular events like heart attack or stroke in patients with risk factors for these events who smoke now or smoked in the past, as well as an increased risk of blood clots in legs or lungs and new (secondary) cancers like lymphoma, especially in patients who smoke now or smoked in the past. The most common side effects of Jakafi for certain types of MF and polycythemia vera include: low platelet or red blood cell counts, bruising, dizziness, headache, and diarrhea. Call your doctor for medical advice about side effects. To learn more about these and other risks, please read the Important Safety Information at https://www.jakafi.com/. Please see the Full Prescribing Information at https://www.jakafi.com/pi/pi, which includes a more complete discussion of the risks associated with Jakafi. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also report side effects to Incyte Medical Information at 1-855-463-3463. Sponsored by Incyte Corporation. Jakafi is a registered trademark of Incyte. © 2020, Incyte Corporation. MAT-JAK-03731 01/22