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Siegrid Yu, MD UC San Francisco Helen Diller Family Comprehensive Cancer Center Mohs surgery is a highly effective and precise surgical technique used to treat skin cancer. Developed by Dr. Frederic Mohs in the 1930s, this procedure has revolutionized the field of dermatology. It involves removing layers of cancerous tissue one at a time and examining them under a microscope until no abnormal cells are detected. The main advantage of Mohs surgery is its high cure rate, which exceeds 95% for most types of skin cancer. This is because it allows for complete removal of the tumor while sparing as much healthy tissue as possible. Additionally, the meticulous examination of each layer ensures that all cancer cells are eradicated, minimizing the risk of recurrence. Another benefit of Mohs surgery is its cosmetic outcome. By selectively removing only cancerous tissue, this technique preserves healthy skin and minimizes scarring. This makes it particularly suitable for treating tumors located in aesthetically sensitive areas such as the face or hands. Mohs surgery offers immediate results. Unlike other treatments that require waiting for lab analysis or multiple surgeries, this procedure provides real-time feedback on tumor removal during the operation itself. This allows surgeons to precisely target affected areas and ensure complete eradication of cancer cells. Mohs surgery has emerged as a gold standard treatment for skin cancer due to its high cure rate, excellent cosmetic outcomes, and immediate results. Its precision and effectiveness make it an invaluable tool in combating this prevalent disease while preserving patients' quality of life.