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Dr. Ilya Shadrin, an MD, PhD, currently at Duke University Hospital in Durham NC, and who completed his Residency at Mayo Clinic in Rochester, MN, shares discoveries from his article appearing in the January 2023 issue of Mayo Clinic Proceedings, where, as noted for the past 70 years, he found the left internal mammary artery to be the gold standard for coronary artery bypass grafting associated with spontaneous regression of downstream atheromatous plaques. Numerous molecular pathways related to inflammation, cell proliferation and migration, thrombosis and vasodilation have been implicated in the success of left internal mammary artery grafting. Dr. Shadrin notes understanding the protective secretory profile germane to the vascular cells comprising the left internal mammary artery in relation to other surgical conduits serves to unlock new opportunities in the development of platforms to reverse coronary artery disease. Available at: https://mayocl.in/3hVKpmE