The Serotonin Code: Ancient Origins of the 5-HT2B Serotonin Receptor скачать в хорошем качестве

The Serotonin Code: Ancient Origins of the 5-HT2B Serotonin Receptor

This 7‑min micro‑lecture explores the evolutionary roots and developmental significance of the 5‑HT2B serotonin receptor, drawing on Moutkine et al.’s 2019 publication "Evolutionary considerations on 5‑HT2 receptors" as our guide (full citation below). The lecture examines evidence suggesting that the 5‑HT2B receptor may be the ancestral member of the 5‑HT2 receptor subfamily, emerging during the transition from invertebrates to vertebrates. A key insight is the receptor’s unique genomic position: the Htr2b gene is physically nested within the Psmd1 proteasome gene, a rare arrangement that first appeared in pre‑vertebrates and has been preserved through multiple rounds of genome duplication. This remarkable conservation implies strong selective pressure and hints at a foundational biological role. Beyond its evolutionary history, the 5‑HT2B receptor plays a crucial part in embryonic development, influencing heart formation, blood system development, and neural crest cell differentiation. Studies across species — from lampreys to mammals — show that blocking this receptor leads to severe developmental abnormalities, underscoring its essential function. Ultimately, understanding this ancient genetic association may shed new light on the pathophysiological roles of serotonin in modern medicine, offering clues about how different serotonin receptor subtypes evolved and why they contribute differently to health and disease. SCIENTIFIC ABSTRACT Serotonin is a neurotransmitter widely conserved from ancient organisms lacking nervous systems through man, and its presence precedes the appearance of nervous systems on both developmental and evolutionary time scales. Serotonin receptor subtypes diversified approximately at the time period during which vertebrates diverged from invertebrates. The biological and clinical importance of serotonin receptors, may benefit from studies on their evolution. Although potentially informative about their pathophysiological functions, reviews on this topic are sparse. Several observations support basic functions mediated by serotonin, both in periphery and central nervous system. In particular, 5-HT2B receptors have been implicated in embryonic development, including cell proliferation, survival, and/or differentiation, in either neural crest cell derivatives, myeloid cell lineage, or heart embryogenesis. In this review, we collected existing data about the genomic association between the RPN2 proteasome subunit gene Psmd1 and the 5-HT2B receptor gene Htr2b. We discuss about the possibility that, during genome duplications, a single copy of this pair of genes has been conserved, suggesting a strong selective pressure. Many basic physiological functions in which serotonin system is involved could be linked to the early association of these two genes in pre-vertebrates. Their evolutionary association highlights the possibility that the 5-HT2B receptor gene, Htr2b, is the common ancestor of 5-HT2A/2B/2C-receptor subfamily. Disentangling these possibilities could bring new understanding of the respective importance of these receptors in pathophysiology of serotonin. SOURCE Moutkine, I., Collins, E. L., Béchade, C., & Maroteaux, L. (2019). Evolutionary considerations on 5‑HT2 receptors. Pharmacological Research, 140, 14–20. #serotonin #5ht2a #5HT2B #neuroscience #neurodevelopment #evolutionarybiology #evolution #braindevelopment #mentalhealthresearch #scienceeducation ‪@BrennaBrayPhD‬ ‪@NIHVideoCast‬ ‪@NIMHgov‬ ‪@NIH_NCCIH‬ ‪@BBRFoundation‬ ‪@TheAPAVideo‬ ‪@AmericanPsychiatricAssociation‬ ‪@PsychedelicsToday‬ ‪@nunmedu‬ ‪@naropauniversity‬ ‪@naropaallianceforpsychedel7015‬ ‪@neurochallenged‬ ‪@Neuroscience‬ ‪@BosqueNeuroscience‬ ‪@prsneurosciences‬ ‪@neuroscienceonline2420‬ ‪@Spirituelles-Neurowissen-Joy‬ ‪@neuroscienceresearchlab1192‬ ‪@PsychedelicSpotlight‬ ‪@PortlandPsychedelicSociety‬ ‪@ImaneElmoutkine‬ ‪@psychedelicsupport‬ ‪@PsychedelicSpotlight‬ ‪@PsychedelicsCom‬ ‪@PsychedelicsToday‬ ‪@PsychedelicsReview‬ ‪@thepsychedelics7680‬ ‪@UnivParis1‬