White Board Series (Audio Version): Serotonin's Role in Development for Sensory Maps скачать в хорошем качестве

White Board Series (Audio Version): Serotonin's Role in Development for Sensory Maps

In this whiteboard-style episode, we delve into serotonin's pivotal yet underrated role in prenatal brain development and autism, tracing its origins from maternal tryptophan (primarily gut-derived in the first trimester) through fetal production shifts across trimesters. Derived from an aromatic amino acid, serotonin drives neurogenesis, migration, and critical wiring of thalamo-cortical connections—especially for the somatosensory cortex (S1)—shaping mini-columns and sensory maps. We contrast diffusion (chaotic, unpruned connections leading to overload) with refinement (clear boundaries via proper pruning), explaining how imbalances foster sensory chaos, poor signal-to-noise discrimination, and inward bias in the autistic phenotype, while setting the stage for comparisons with T3 thyroid hormone's developmental influence. Daylight Computer Company, use "autism" for $50 off at https://buy.daylightcomputer.com/autism Chroma Light Devices, use "autism" for 10% discount at https://getchroma.co/?ref=autism Fig Tree Christian Golf Apparel & Accessories, use "autism" for 10% discount at https://figtreegolf.com/?ref=autism Cognity AI for Autistic Social Skills, use "autism" for 10% discount at https://thecognity.com 00:00 Serotonin role in pregnancy/development; beyond mood, neurogenesis/synaptogenesis from neuralation, Tryptophan Basics From aromatic amino acid tryptophan (one codon); distinct TPH1 (peripheral/gut) vs TPH2 (brain) pathways 02:41 Neuralation & Trimesters First trimester: all maternal serotonin (95% gut); regulates cell proliferation; neuroepithelial cells form brain divisions 05:46 Mesencephalon Details Doesn't subdivide; key roles: sensory integration, motor, external attention orientation—highly relevant to autism 07:58 Serotonin Sources Shift Second trimester: fetus starts own production; maternal still significant; builds placenta/umbilical physiology 11:12 Thalamus & Sensory Maps Serotonin wires thalamus to cortex (esp. S1 somatosensory ＞ V1/A1); structures mini-columns for sensory processing 15:38 Mini-Columns Structure 6 cortical layers; thalamus inputs to layer 4; layers 2/3 for experience/intelligence; autistic: narrower neuropil (~40-60μm) 20:51 Diffusion vs Refinement Serotonin prunes connections; abnormal levels → diffusion (weak, competing links, chaos) vs refinement (clear edges) 28:42 Signal-to-Noise Issues Diffusion causes poor boundaries, overload; inward bias ("autism" meaning self) as adaptation to external chaos 35:59 Critical Period Implications Prenatal setup affects salience network; early detection/intervention potential; serotonin vs T3 comparison upcoming. X: https://x.com/rps47586 YT:    / @fromthespectrum   email: info.fromthespectrum@gmail.com