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High Tolerance ≠ High Risk Welcome to another cutting-edge episode of cannabis clarity 🎥 with Dr. Benjamin Caplan—family physician, author, researcher, and one of the world’s foremost experts in medical cannabis care. 🌱 In this talk, Dr. Caplan breaks down one of the most misunderstood concepts in cannabis medicine: tolerance. Why does your go-to edible suddenly feel like a placebo? 😩 What’s really happening inside your brain when weed stops working? And is needing more cannabis a red flag—or just a feature of being human? 👨⚕️ Dr. Caplan, with experience caring for over 300,000 cannabis patients and leading CEDclinic.com, brings clarity, nuance, and even some much-needed humor to the science of tolerance. This isn’t just pharmacology—it’s a masterclass in how your body adapts, protects, and rebalances itself. ⸻ 🔍 What You’ll Learn in This Episode: • Tolerance ≠ Addiction: Why confusing these can harm patients • How THC triggers your brain’s cellular defense system (hint: it’s smart) • Why estrogen may change how THC hits, week by week • How isolates vs full-spectrum products influence your tolerance trajectory • What “receptor retreat” really means and why it happens • CBD and “reverse tolerance”: myth or mechanism? • Why daily cannabis doesn’t mean dysfunction—and may reflect adaptation • Personalized medicine: what cannabis users are teaching the medical world • Tolerance strategies: rotate, reset, rebalance—not just abstain ⸻ 🧬 Topics Covered (Organized for Viewer Navigation) • Introduction and Cannabis Public School recap • What tolerance is (and isn’t) • Tolerance vs dependence vs addiction • CB-1 receptor mechanics & GRKs/Beta Arrestins • THC vs CBD mechanisms • Full-spectrum vs isolate tolerance differences • Hormonal influences on cannabis response • Consumption methods and their impact on tolerance • Functional vs problematic tolerance • Evolutionary biology of cannabis adaptation • Strategic reset options (without quitting cold turkey) • Closing insights: Cannabis as a tool for teaching medicine ⸻ 💡 You might walk away from this video with more questions than answers—and that’s a good thing. The truth is, your brain’s adaptation to cannabis isn’t a bug… it’s a built-in feature. And by understanding it, we all become better at tuning into the real signals our bodies send. So whether you’re: • A patient feeling like your edible betrayed you • A clinician unsure how to talk about tolerance • Or just a curious brain who enjoys knowing more than the average bear 🐻… 🌿 This one’s for you. ⸻ 🌐 Want to learn more? • Read the best-selling guide to cannabis care: “The Doctor-Approved Cannabis Handbook” (Find it at Amazon under “Doctor-Approved Cannabis Handbook”) • Explore clinical cannabis care options at CEDclinic.com • Learn more about Dr. Caplan’s work at BenjaminCaplan.com or CaplanCannabis.com • Follow Dr. Caplan on Instagram → instagram.com/drbenjamincaplan • Or catch daily commentary at X.com/drcaplan ⸻ 🔥 Be sure to share questions, concerns, and support for viewers to engage with the comments below the video! 🔥 👇👇👇 💬 Let me know in the comments: • Have you noticed your tolerance changing? • What methods help you reset? • Has your provider ever explained why this happens? 👇👇👇 ⚡ Don’t forget to like 👍, comment 💬, and subscribe 🔔 for more videos on cutting-edge cannabis care. 👀 And hey, stick around—we’ve got more mind-blowing truths about cannabis science, stigma, sleep, senior care, and everything in between. Join this channel to get access to perks: / @drcaplan