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Understanding the Oxyhemoglobin Dissociation Curve is essential for mastering oxygen transport physiology. In this third part of the Oxygen Transport series, we break down the curve in a clear, clinically relevant, and exam-focused manner. This video explains: Clarifying the basics. How is Oxygen tension different from Oxygen saturation What is the difference between, PaO2, SaO2 and SpO2? The shape of the oxyhemoglobin dissociation curve and why it is sigmoidal It's clinical significance . The relationship between PaO₂ and SaO₂ What causes right and left shifts The Bohr effect and its physiological significance How this concept applies to anesthesia, intensive care, and emergency medicine Topics covered (Timestamps) 00:00 Introduction 00:56 Clarifying the basics (SaO2, SpO2, PaO2, oxygen saturation, blood oxygen tension) 05:26 ODC (Oxyhemoglobin dissociation curve) basics 08:00 p50 value and its significance 11:53 Rightward shift of ODC 12:28 The physiological mechanism underlying rightward shift 15:49 Leftward shift of ODC We go beyond memorisation and focus on understanding — so you can interpret arterial blood gases, anticipate physiological changes, and apply the concept in real clinical scenarios. Whether you are preparing for medical school exams, postgraduate anesthesia exams, or strengthening your foundation in respiratory physiology, this video will help you connect theory to practice. This is Part 3 of the Oxygen Transport series. Be sure to watch Part 1 (Oxygen Content and Hemoglobin) Link: • Oxygen content & Hemoglobin| Oxygen Transp... and Part 2 (Hemoglobin Pathologies) to build a complete understanding of oxygen delivery. Link: • Hemoglobin Pathologies| Oxygen Transport P... Subscribe for structured, high-yield physiology explained with clinical clarity. Kindly drop a comment for any corrections, amendments, requests, or anything in particular.