Session 3: Yoichiro Masuda MD, PhD, Lecturer, The Jikei University School of Medicine скачать в хорошем качестве

Session 3: Yoichiro Masuda MD, PhD, Lecturer, The Jikei University School of Medicine

Title: V1 Projection Zone Signals in Human Macular Degeneration Depend on Task, not Visual Stimulus Juvenile Macular Degeneration (JMD) due to retinal dystrophy results in a loss of central visual field due to almost symmetrical impairment of retinal cells in both eyes. Until the onset of JMD, the primary visual cortex (V1) develops structures and functions essential for 'seeing' from postnatal to the critical period. However, with the onset of JMD, V1 loses its feedforward inputs from the damaged retina, leading to a loss of its 'seeing' function or visual field (referred to as the Lesion Projection Zone: LPZ in the context of retinal lesions). Despite this, it has been reported that the V1-LPZ demonstrates 'task-dependent responses' and remains active. Why would the 'task-dependent responses' be observed in the V1-LPZ, which has lost its function of 'seeing'? In this lecture, I would like to focus on these 'task-dependent responses' of the V1-LPZ, uniquely observed in JMD, and consider retinal dystrophy from the perspective of the structure and function of the visual cortex.