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Levamisole hydrochloride, marketed as Levamod and Luvsole, is a synthetic imidazothiazole derivative with anthelmintic and immunomodulatory properties. Here's a summary of its pharmacology: Mechanism of Action: As an anthelmintic, Levamisole acts as a nicotinic receptor agonist, causing sustained contraction of the somatic muscles of helminths. This leads to paralysis and expulsion of the worms. It also modulates cell-mediated immunity by enhancing phagocytosis and restoring delayed hypersensitivity reactions. Indications: Used to treat ascariasis (roundworm) and hookworm infections. As an immunomodulator, it has been used in cancer therapy (e.g., colon cancer) and autoimmune conditions like rheumatoid arthritis. Dosage: For helminth infections: Administered orally, typically as a single dose of 150 mg for adults or weight-based dosing for children. As an immunomodulator: Dosage varies depending on the condition being treated. Side Effects: Common: Nausea, vomiting, diarrhea, headache, dizziness, and rash. Serious: Agranulocytosis (low white blood cell count), which requires careful monitoring. Precautions: Contraindicated in patients with hypersensitivity to the drug or blood disorders. Avoid alcohol during treatment due to disulfiram-like reactions. #Levamisole