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Watch the Full Video at https://www.jove.com/v/52559/a-murine.... A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction - a 2 minute Preview of the Experimental Protocol Emily E. Hesketh, Madeleine A. Vernon, Peng Ding, Spike Clay, Gary Borthwick, Bryan Conway, Jeremy Hughes University of Edinburgh, MRC Centre for Inflammation Research; The murine model of irreversible unilateral ureteric obstruction (UUO) is presented together with the model of reversible UUO in which the ureteric obstruction is relieved by anastomosis of the severed ureter into the bladder. These models enable the study of renal inflammation and scarring as well as tissue remodeling. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments