First reported COVID reinfection скачать в хорошем качестве

First reported COVID reinfection

Reinfection First case of reinfection Dr. Kelvin Kia Wang https://hub.hku.hk/cris/rp/rp01384 First case of reinfection, 23 million COVID-19 cases Journal Clinical Infectious Diseases https://edition.cnn.com/2020/08/24/he...   / 1   Not prolonged viral shedding 33-year-old man, good health Immunocompetent First infection 3 days, cough, sore throat, fever, headache Hospitalized Serum at day 10, negative for IgG 26th March Oropharyngeal antigen PCR diagnosis 14th April Discharged asymptomatic 142 days 2nd infection Spain - UK – HK 15th August Oropharyngeal positive at HK airport Hospitalised, remained asymptomatic T, 36.5 HR, 86 BP, 133/94 SaO2, 98 RA CRP, 8.6 mg / L Slightly raised, suggesting acute infection Declining during hospitalisation Hypokalaemia Viral load progressively decreased Serum day 5 of hospitalisation, positive Genome analysis Full sequencing performed after first and second episode Different clade/lineage Truncation of 58 amino acids in the virus genome 23 nucleotide changes 13 of which non-synonymous mutations 4 in the spike protein First strain Mostly close to strains from USA or England collected in March and April Second strain Switzerland and England collected in July and August Evidence Genomics, phylogenetic analysis 142 days, viral shedding (104 days in one pregnant woman) Raised CPR indicating acute infection Patient had recently returned from Europe with July and August strains Implications Unlikely herd immunity can eliminate SARS-CoV-2 Subsequent infections likely to be milder Virus likely to go on circulating in the human population Vaccine will not provide lifelong infection Vaccine studies should include patients who have recovered from COVID People who have had COVID should be vaccinated People who have had COVID should continue with public health measures Residual low level of antibodies may have controlled the second infection WHO https://www.who.int/docs/default-sour... Dr Maria Van Kerkhove I haven't read the study Our expectations, people who are infected with this virus develop an immune response People do develop an immune response, not completely clear yet is how strong and how long lasting Severe, mild, asymptomatic cases, develop an immune response More than 24 million cases On a population level Longitudinal studies, following the same individual underway Inductive thinking, Bottom up Deductive thinking, Top down