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Skin mottling refers to a patchy appearance of the skin that is characterized by discolored areas that are either darker or lighter than the surrounding skin. Mottling can occur in different patterns and can be a sign of various underlying medical conditions. In general, skin mottling can occur due to impaired blood flow to the skin. This can happen in conditions such as sepsis, shock, heart failure, peripheral artery disease, and Raynaud's disease. In these conditions, the body's blood vessels may constrict or dilate inappropriately, leading to uneven blood flow and mottling of the skin. Skin mottling can also be a side effect of certain medications, including chemotherapy drugs and some antibiotics. Other causes of skin mottling can include skin infections, allergic reactions, and autoimmune diseases. If you notice skin mottling, it is important to seek medical attention, especially if it is accompanied by other symptoms such as fever, pain, or difficulty breathing. Your doctor may perform tests to identify the underlying cause and recommend appropriate treatment.