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The human gut microbiome is tightly linked our health. Our analyses of diverse human populations from around the globe, ranging from hunter-gatherer to industrialized, show that the gut microbiome is profoundly influenced by lifestyle. With a large collaborative team, we conducted deep metagenomic sequencing of the gut microbiomes of Tsimane horticulturalists from Bolivia and compared them to those of Hadza hunter-gatherers from Tanzania. We are also investigating whether diet and microbial therapies can address deficiencies in the industrialized gut community. Molecular mechanisms of host-microbial interaction are pursued using an array of technologies and experimental approaches including gnotobiotic and conventional mouse models, quantitative imaging, and a metabolomics pipeline focused on investigating microbiota-dependent metabolites. [6/2025] [Show ID: 40698] Donate to UCTV to support informative & inspiring programming: https://www.uctv.tv/donate Learn more about anthropogeny on CARTA's website: https://carta.anthropogeny.org/ More videos from: CARTA - Mismatch: Human Origins & Modern Disease (https://www.uctv.tv/carta-disease) Explore More Humanities on UCTV (https://www.uctv.tv/humanities) The humanities encourage us to think creatively and explore questions about our world. UCTV explores human culture through literature, history, ethics, philosophy, cinema and religion so we can better understand the human experience. Explore More Science & Technology on UCTV (https://www.uctv.tv/science) Science and technology continue to change our lives. University of California scientists are tackling the important questions like climate change, evolution, oceanography, neuroscience and the potential of stem cells. UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California -- teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world. (https://www.uctv.tv)