Cell Organelles (part 2) скачать в хорошем качестве

Cell Organelles (part 2)

Mastering Cell Organelles, Trafficking, and Metabolism with Dr. Faiza Explore a complete, step-by-step walkthrough of the cell’s organelles and how they work together—from protein and lipid synthesis to packaging, targeting, digestion, detoxification, and energy production. Perfect for medical and life-science students revising cell biology with clinical relevance. 🔬 Key Topics Covered: • Golgi Apparatus: Processing, glycosylation, membrane replenishment, lysosome and secretory vesicle formation; COPI/COPII coats; vesicle targeting via v-SNARE/t-SNARE “lock-and-key” docking and exocytosis • Nucleus & Nucleolus: Nuclear envelope continuity with ER, nuclear pores (importins/exportins), chromatin, ribosome assembly in nucleolus • Ribosomes & ER: Free vs bound ribosomes; rough ER for transmembrane/secreted proteins; smooth ER for lipid/steroid synthesis, drug detox • Vesicles: Transport vs secretory vesicles and size differences; directional trafficking routes • Lysosomes: Acidic pH, ~40 hydrolases, intracellular digestion, regression, autolysis, autophagy; lysosomal storage diseases (e.g., Tay-Sachs, Fabry) • Proteasomes & Ubiquitin: Targeted degradation of misfolded cytosolic proteins • Vaults: Putative nucleo-cytoplasmic transport and role in multidrug resistance • Peroxisomes: Budding (SER/Golgi), oxidative enzymes, β-oxidation of very-long-chain fatty acids, alcohol detox; peroxins and PPAR-mediated proliferation • Mitochondria: Cristae, oxidative phosphorylation, ATP generation, apoptotic regulation, mtDNA (maternal inheritance) • Comparative Tables: Lysosome vs peroxisome—enzymes, pH, origin, functions, disease links 🎓 Learning Objectives: • Trace the secretory pathway from ER → Golgi → vesicles → membrane with molecular targeting signals. • Distinguish membrane-bound vs non–membrane-bound organelles and their unique enzymes. • Explain how cells degrade materials via lysosomes and proteasomes and detox via peroxisomes. • Connect mitochondrial structure to ATP production and apoptosis, and recognize clinical correlations. 💡 Clinical Relevance: • Understand mechanisms behind lysosomal/peroxisomal storage disorders and drug detoxification. • Relate SNARE/coat protein defects to trafficking diseases. • Link mitochondrial dysfunction to multisystem disease presentations. 📚 Learning Resources: Phone: +92 310 7990649 Email: [email protected] Website: https://www.medicoseacademics.com/ Facebook:   / medicoseacademics   Instagram:   / medicoseacademics   YouTube:    / @medicoseacademics   My personal stamp: Dr. Faiza | Medicose Academics Dr. Faiza Assistant Professor of Physiology MBBS (AIMC, lahore, Best Graduate) FCPS (Physiology) CHPE (Certificate in Health Professional Education) DHPE (Diploma in Health Professional Education) DHPE (Masters in Health Professional Education) MBA (Masters of Business Administration) MPH (Masters of Public Health) LinkedIn:   / faizaikram   Tags: Cell Organelles, Golgi Apparatus, Endoplasmic Reticulum, Rough ER, Smooth ER, Vesicular Transport, COPI COPII, SNARE Proteins, Lysosomes, Peroxisomes, Proteasome, Vault Complex, Mitochondria, Oxidative Phosphorylation, Autophagy, Ubiquitin, Nuclear Pore Complex, Cell Biology, Medical Education, Cellular Metabolism