MMR vaccine and COVID immunity скачать в хорошем качестве

MMR vaccine and COVID immunity

Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 Patients https://mbio.asm.org/content/11/6/e02... The measles-mumps-rubella (MMR) vaccine Theorized to provide protection against coronavirus disease To determine whether any MMR IgG titers are inversely correlated with covid severity Comparing MMR titers to recent COVID-19 severity levels. The MMR II group 50 subjects who would primarily have MMR antibodies from the MMR II vaccine Comparison group 30 subjects consisted of those who would primarily have MMR antibodies from sources other than MMR II Including prior measles, mumps, and/or rubella illnesses Results in the MMR group Significant inverse correlation (rs = −0.71, P less than 0.001) Between mumps virus titers and COVID-19 severity Results in the comparison group There were no significant correlations between mumps IgG titers and severity in the comparison group Results in both groups No correlation between between severity and measles or rubella titers in either group Scale of the observation Mumps titers of 134 to 300 arbitrary units (AU)/ml (n = 8), functionally immune or asymptomatic Less than 134, (n=17) all had mild symptoms Less than 75, (n=11) all had moderate symptoms Less than 32, all who had been hospitalized and had required oxygen Our results demonstrate that there is a significant inverse correlation between mumps titers from MMR II and COVID-19 severity Four important points Young children are largely spared from severe disease Second, numerous countries have COVID-19 death rates that are as low as 1% of the death rates of other countries Many people, despite prolonged close contact with someone who is COVID-19 positive, never test positive themselves Nearly half of people who test positive for COVID-19 are asymptomatic Mechanism of action Sequence homology between both mumps and measles and rubella with SARS-CoV-2 After two doses 97% protected against measles 88% against mumps 97% against rubella NHS site https://www.nhs.uk/conditions/vaccina... Born between 1970 and 1979, as you may have only been vaccinated against measles Born between 1980 and 1990, as you may not be protected against mumps Bradford Hill Strength of association Consistency Reproducibility Specificity Temporality Biological gradient, dose response Plausibility Coherence with lab findings Experiment Reversibility