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Learn how the kidneys regulate water balance and how ADH (vasopressin) controls serum osmolality and urine concentration. This module explains the physiology of water handling and the central role of ADH in maintaining homeostasis. In this video you’ll learn: • What “water handling” means physiologically • How ADH is regulated by plasma osmolality and volume • How ADH acts on the collecting duct to control water reabsorption • How urine becomes dilute or concentrated • Clinical implications for hyponatremia, SIADH, and diabetes insipidus This lesson is part of the ABC Kidney renal physiology series and is designed for: Medical students, residents, fellows, and clinicians building a framework for fluid and electrolyte disorders. 📌 Topics: water balance, ADH physiology, vasopressin, osmolality, urine concentration, hyponatremia, SIADH, diabetes insipidus, renal physiology This content is for educational purposes only and is not intended as medical advice 🔬 Part of the ABC Kidney physiology series, focused on making kidney physiology intuitive, visual, and clinically meaningful. www.abckidney.com : visit for a more immersive-interactive educational experience!