Novel Application of SPR to Study Amyloidogenic Peptides and Proteins скачать в хорошем качестве

Novel Application of SPR to Study Amyloidogenic Peptides and Proteins

For more info, visit http://www.bio-rad.com/yt/4/ProteinIn.... An increasing number of diseases are now being associated with misfolding, aggregation, and tissue deposition of specific proteins. A well-known example is Alzheimer's disease (AD). The condition is characterized by the aggregation of β-amyloid peptides (Aβ1--40 and Aβ1--42), which form amyloid plaques. The plaques are mainly composed of insoluble Aβ fibrils formed by fibrillogenesis. However, recent evidence suggests a pathogenic role for soluble oligomers appearing early in the fibrillogenesis process. This webinar illustrates unconventional applications of surface plasmon resonance (SPR) to measure the kinetics of the elongation of Aβ1--42 fibrils and recognize soluble Aβ1--42 oligomeric species, which cannot be achieved by other techniques. These approaches are very useful in screening mutations or potential anti-amyloidogenic drugs for their effects on fibrillogenesis and the formation of toxic oligomers. Presenter: Marco Gobbi Head, Laboratory of Pharmacodynamics and Pharmacokinetics Istituto di Ricerche Farmacologiche Mario Negri Milano Italy http://www.bio-rad.com/evportal/desti... We Are Bio-Rad. Our mission: To provide useful, high-quality products and services that advance scientific discovery and improve healthcare. At Bio-Rad, we are united behind this effort. These two objectives are the driving force behind every decision we make, from developing innovative ideas to building global solutions that help solve our customers' greatest challenges. Connect with Bio-Rad Online: Website: http://www.bio-rad.com/ LinkedIn:   / 1613226   Facebook:   / biorad   Twitter:   / bioradlifesci   Instagram: @BioRadLabs Snapchat: @BioRadLabs