How "Heavy Hydrogen" makes Drugs work: Deuterium in Pharmaceuticals, Organic Chemistry & Synthesis скачать в хорошем качестве

How "Heavy Hydrogen" makes Drugs work: Deuterium in Pharmaceuticals, Organic Chemistry & Synthesis

Organic chemistry does not only use abundant forms of atoms but also rare isotopes such as deuterium - the heavy form of hydrogen. Addition of "the D" can completely transform a molecule's reactivity and pharmacokinetic properties. Watch this to find out more about the physical chemistry, biochemistry and organic synthesis associated with Deuterium and more specifically, the discovery route and large-scale process behind the second deuterated drug to be approved by the US FDA, deucravacitinib (Sotyktu). https://total-synthesis.com/organic-c... 🧑‍🎓➡️ Free organic chemistry practice problems   / totalsynthesis   🚀 Thanks to all channel supporters!!!   / totalsynthesis_official   👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! Please drop a like and comment to support the video's visibility, as well as activate notifications and subscribe to the channel so you do not miss out on future videos - they are coming! 00:00 Why you should care about D 01:40 Deuterium's discovery and application in medicinal chemistry (deutetrabenazine) 06:44 Psoriasis landscape, key molecules and mechanisms of action 09:08 Deucravacitinib Tyk 2 deep dive and outlook 12:33 Discovery chemistry route overview 14:54 Process chemistry route deep dive Main paper: Development of a Commercial Process for Deucravacitinib, a Deuterated API for TYK2 Inhibition; https://pubs.acs.org/doi/10.1021/acs.... Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165; https://pubs.acs.org/doi/abs/10.1021/... Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. Some recommended books on organic synthesis: Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures) Thumbnail RHS image by aleksandarlittlewolf on Freepik