Targeting Glioblastoma Invasion and Survival with Cannabis-Derived Flavonoids - Akeem Gardner, LLB скачать в хорошем качестве

Targeting Glioblastoma Invasion and Survival with Cannabis-Derived Flavonoids - Akeem Gardner, LLB

Tags: Cannflavins, Cancer Research, Cannflavin A, Cannflavin B, Flavonoids, Cannabis Research, Science Akeem Gardner, LLB, presents "Targeting Glioblastoma Invasion and Survival with Cannabis-Derived Flavonoids" at CannMed 23. 0:00 Intro 0:29 Cannflavins 2:12 Modulators of Arc Protein Expression 3:52 Cannflavins Reduced Nuclear Arc Expression 4:45 Cannflavins Reduced Arc mRNA Expression 5:42 Cannflavins Effect on TrkB Activation 7:04 Cannflavins Effect on Pathways Downstream of TrkB 8:30 TrkB Dysregulation in Disease 9:53 ANA12 - TrkB Inhibitor 10:34 Impact of TrkB Inhibition by Cannflavins on GBM Cell Viability 11:13 Lactate Dehydrogenase (LDH) Cytotoxicity Assay 11:43 Cannflavins on GBM Cell Migration 12:38 Impact of TrkB Inhibition by Cannflavins on GBM Cell Invasion 13:28 Summary & Significance 14:35 Upcoming Research 16:14 Acknowledgements 16:36 Q&A Cannflavins A and B are cannabis-enriched flavonoids known to reduce inflammation via biosynthesis inhibition of pro-inflammatory mediators1. Accumulating evidence also suggest that these prenylated flavones may have neuroprotective and anti-cancer properties2, but the mechanisms responsible for these effects remain elusive. While screening for novel modulators of receptor tyrosine kinases in neurons, our group found that cannflavins can prevent TrkB receptor activation by the growth factor BDNF3. Since signaling by TrkB can be a factor in the biology of various types of brain tumors4, and that targeting this pathway may be an effective strategy to limit the growth of aggressive cells, we aimed to test whether cannflavins can be leverage to affect the survival, proliferation, and migration of glioblastomas (GBMs). Learn More about CannMed: https://cannmedevents.com/