Why the Time of Day You Get Cancer Treatment Could Save Your Life - Part 1 скачать в хорошем качестве

Why the Time of Day You Get Cancer Treatment Could Save Your Life - Part 1

What if the timing of your cancer treatment mattered as much as the treatment itself? In this cutting-edge episode, Dr. Nathan Goodyear is joined by Dr. Jason Williams of the Williams Cancer Institute to explore one of the most overlooked but transformative insights in oncology today: the circadian rhythm of the immune system. This isn’t theory—it’s practice. Rooted in peer-reviewed research and real patient experience, this conversation unpacks how aligning cancer treatments with the body’s natural immune cycle can significantly improve outcomes, especially in immunotherapy. From biopsy timing to imaging innovations, this discussion lays the foundation for the next era of precision cancer care. Full episode outline, sources, and timestamps are listed below. Summary Dr. Goodyear and Dr. Williams examine how cancer treatments—immunotherapy, radiation, chemotherapy—can be optimized by synchronizing them with the immune system’s circadian rhythm. They discuss recent studies showing how immune checkpoint efficacy, PD-L1 expression, tumor oxygenation, and biomarker cycles all follow daily patterns. The implications are massive: timing may affect treatment response, toxicity, and overall survival. The conversation also highlights systemic barriers to innovation, why biopsy should include therapeutic intent, and how patients can advocate for themselves within a rigid healthcare system. Key Takeaways Timing is just as important as treatment in cancer care. The immune system follows a circadian rhythm of activation and suppression. PD-L1 expression and immunosuppressive cells peak at different times of day. Administering therapy at the wrong time may reduce survival outcomes. SBRT-PATHY shows 95% response when timed with immune activation. Targeting hypoxic tumor zones increases response and reduces resistance. Biopsy should be viewed as the first opportunity to treat, not just diagnose. Intratumoral vaccines like flu and hepatitis B can boost local immune responses. Patients must become advocates, educators, and force multipliers in their own care. Circadian Rhythms & Immunity: The immune system follows a natural 24-hour cycle. Killer T-cells, dendritic cells, and cytokines all fluctuate in strength depending on the time of day. Morning vs. Night Treatments: Studies reveal up to twice the response rate for certain immunotherapies administered during peak immune activity. Intratumoral Therapy Synergy: Ablation + immunotherapy works best when the immune system is primed—early morning and early afternoon show promise in clinical outcomes. Disrupted Sleep & Cancer Progression: Poor circadian alignment is linked to increased metastasis, chemo resistance, and poor overall survival rates. Chronotherapy: The growing field of time-based medical intervention, especially in oncology. Summary 1. Immune Timing = Treatment Timing – Your immune system isn’t equally effective all day long. 2. Chronotherapy is the Future – Integrating timing into treatment protocols may boost efficacy while reducing side effects. 3. Personalized Cancer Care – Biological clocks vary between individuals. The best treatment time for you might be different than for someone else. 4. Don’t Let Hospital Schedules Dictate Outcomes – Advocate for time-specific treatment windows if you're in care. References and Research Links Tubin, S. et al. (2019). Time-synchronized immune-guided SBRT. Radiation Oncology. http://doi.org/10.1186/s13014-019-1423-9 Karaboué, A. et al. (2024). Circadian timing and checkpoint inhibitor efficacy. British Journal of Cancer. http://doi.org/10.1038/s41416-024-027... Fortin, B.M. et al. (2024). Circadian control of tumor immunosuppression. Nature Immunology. http://doi.org/10.1038/s41590-024-018... Sound Bites "Biopsy timing is crucial for treatment." "The healthcare system needs to change." "Patients need to educate their doctors." 📌 Don’t forget to subscribe and turn on notifications for more cutting-edge discussions on integrative cancer treatments. #cancerfree #cancercare #immunotherapy #cancertreatments