Thomas Sharpton – Disentangling the exposome’s impact on the gut microbiome and health | MVIF41 S05 скачать в хорошем качестве

Thomas Sharpton – Disentangling the exposome’s impact on the gut microbiome and health | MVIF41 S05

Title of the presentation: Disentangling the exposome’s impact on the gut microbiome and health Speaker: Thomas Sharpton More info on this event: https://www.microbiome-vif.org/en-US/... Join us at the next meeting (free registration!): https://www.microbiome-vif.org/ And you can join us on Twitter:   / microbiomevif   Abstract of this talk: Extensive evidence demonstrates that gut microbes can mediate how exposure to environmental agents, including nutrients, pollutants, and parasites, impacts health. Consequently, the effort to manage vertebrate health benefits from defining how different environmental agents interact with the microbiome to drive physiology. This effort, however, remains bottlenecked by the extensive scope and variation of exposure. The zebrafish model system offers an opportunity to alleviate this bottleneck and study these interactions at scale, as it affords access to large sample sizes, automated exposure and phenotyping platforms, and short generation times. In this presentation, I summarize the utility and potential for the zebrafish model system to accelerate our understanding of how the exposome and microbiome interact to impact health. I also introduce key zebrafish research analytical and experimental tools that we and others innovated to this end, including longitudinal sampling designs, high-throughput germ-free fish assays, and strategies for multi-omic data integration. Finally, I will discuss recent research we have conducted that exemplifies the utility and impact of this model system for microbiome research. This discussion will include our recent characterization of how exposure to pollutants affects zebrafish gut microbiome assembly to impact larval fish behavior, and underscores the importance of defining the environmental determinants of dysbiosis in the effort to resolve and preserve health-promoting gut microbiota.