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Dr. Monika Harvey ‘Dual -Route models of visual processing’: implications for stroke rehabilitation and understanding of spatial biases A vast majority of stroke patients with right hemisphere lesions show hemispatial neglect, a severe visuospatial impairment, where they fail to perceive items presented in the contralateral part of space. Currently, it is strongly debated whether these patients also fail to reach out and grasp objects presented in that same space. Describing a range of studies recently carried out in these patients, I will argue that immediate on-line actions such as reaching and grasping for single objects are not impaired. I will also show that neglect patients have difficulties in delayed and anti-pointing tasks which require explicit off-line, allocentric processing. Moreover using voxel-based lesion-symptom mapping (VLSM), we found that the anatomical areas critically associated with these off-line deficits are located in the temporal lobes. These areas are anatomically distinct from those implicated in direct on-line reaching and grasping. I will argue that neglect patients present action deficits only when the actions tap into more perceptual representations, thought to rely on ventral visual stream processing. Visual dorsal stream processing seems to be spared in these patients. Importantly, I will show that this spared visual dorsal steam processing can be exploited successfully for stroke rehabilitation. The second part of my talk will cover spatial biases in healthy participants. A systematic leftward bias (pseudoneglect) is typically exhibited by healthy young adults during performance of attention tasks. At present the neural correlates underlying the modulation of this bias remain unknown. I will argue that bias level depends on observer subtype as well as the extent to which the spatially dominant right hemisphere is engaged by the combination of stimulus and endogenous state during performance of the task.