Frank Harrell: "Longitudinal Ordinal Models as General Framework for Medical Outcomes" Ann Arbor ASA скачать в хорошем качестве

Frank Harrell: "Longitudinal Ordinal Models as General Framework for Medical Outcomes" Ann Arbor ASA

Dr. Harrell received his PhD in Biostatistics from UNC in 1979. Since 2003 he has been Professor of Biostatistics, Vanderbilt University School of Medicine, and was the department chairman from 2003-2017. He was Expert Statistical Advisor for the Office of Biostatistics for FDA CDER from 2016-2020. He is Associate Editor of Statistics in Medicine, and a member of the Scientific Advisory Board for Science Translational Medicine. He is a Fellow of the American Statistical Association and winner of the Association’s WJ Dixon Award for Excellence in Statistical Consulting for 2014. His specialties are development of accurate prognostic and diagnostic models, model validation, clinical trials, observational clinical research, cardiovascular research, technology evaluation, pharmaceutical safety, Bayesian methods, quantifying predictive accuracy, missing data imputation, and statistical graphics and reporting. Abstract Univariate ordinal models can be used to model a wide variety of longitudinal outcomes, using only standard software, through the use of Markov processes. This talk will show how longitudinal ordinal models unify a wide variety of types of analyses including time to event, recurrent events, continuous responses interrupted by events, and multiple events that are capable of being placed in a hierarchy. Through the use of marginalization over the previous state in an ordinal multi-state transition model, one may obtain virtually any estimand of interest. Both frequentist and Bayesian methods can be used to fit the model and draw inferences.