This Is How Nicolaou Do Synthesis (Total Synthesis Of Trioxacarcin D) скачать в хорошем качестве

This Is How Nicolaou Do Synthesis (Total Synthesis Of Trioxacarcin D)

Today, I’m breaking down one of the most legendary achievements in organic chemistry — the total synthesis of Trioxacarcin D by K. C. Nicolaou and his coworkers. In this video, we’ll explore how Nicolaou tackled this insanely complex natural product step by step — from the anthraquinone core construction to the installation of the spiroepoxide and the two sugar moieties. You’ll see how each key reaction — from Hauser–Kraus annulation and Baylis–Hillman reaction to Davis chiral oxaziridine oxidation — fits into the big picture. We’ll also break down the mechanism of Trioxacarcin’s DNA alkylation, explaining why the epoxide ring is essential for its anticancer activity, and why Type I and Type II Trioxacarcins show such different biological properties. If you love natural product total synthesis, reaction mechanisms, and the art of complex molecule construction, this is your video. ---------------------------------------------------------------------------------------------------------------------------------------------- Ref: Classics in Total Synthesis IV: New Targets, Strategies, Methods by by Kyriacos Costa Nicolaou. Total Synthesis of Trioxacarcins DC-45-A1, A, D, C, and C7″-epi-C and Full Structural Assignment of Trioxacarcin C. https://doi.org/10.1021/jacs.5b12687 Total Synthesis of Trioxacarcin DC-45-A2. https://doi.org/10.1002/anie.201410369 An efficient glycosylation protocol with glycosyl ortho-alkynylbenzoates as donors under the catalysis of Ph3PAuOTf. https://doi.org/10.1016/j.tetlet.2008... 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in acetic acid, a convenient new reagent for the synthesis of aryl ketones and aldehydes via benzylic oxidation. https://doi.org/10.1021/jo00254a035 ----------------------------------------------------------------------------------------------------------------------------------------------