Take Your Organic Synthesis To The Next Level: Total Synthesis Of (−)-Psathyrin A (3D Visualization) скачать в хорошем качестве

Take Your Organic Synthesis To The Next Level: Total Synthesis Of (−)-Psathyrin A (3D Visualization)

In this video, we break down the total synthesis of (−)-Psathyrin A, a fascinating diterpene natural product with a complex 6/4/5/5 tetracyclic skeleton and multiple quaternary stereocenters. You’ll see how challenging transformations — including MHAT cyclization, Conia-ene reaction, Suzuki coupling, Meinwald rearrangement, Barton–McCombie deoxygenation, and Luche reduction — all come together to build this unique target. We’ll explore: How to construct a strained four-membered cyclobutane ring The role of radical chemistry in modern organic synthesis Step-by-step mechanisms with 3D molecular visualization Key strategies used in natural product synthesis to control stereochemistry and regioselectivity This synthesis was achieved by Prof. Mingji Dai’s group at Emory University, and it’s a perfect case study if you’re learning advanced synthetic organic chemistry. If you want to level up your understanding of organic chemistry mechanisms, natural product total synthesis, and see how cutting-edge strategies are applied in real research, this video is for you. 🔬 Topics covered: Organic Synthesis | Total Synthesis | Natural Products | Psathyrin A | Radical Chemistry | Cross-Coupling Reactions | 3D Molecular Structures | Organic Chemistry Education ------------------------------------------------------------------------------------------------------------- Attribution: Vector graphics in this video Designed by Freepik. http://www.freepik.com/ starline - Freepik.com. https://www.freepik.com/free-vector/f... ------------------------------------------------------------------------------------------------------------- Reference: Total Synthesis of (−)-Psathyrin A Enabled by Radical Cyclization. https://doi.org/10.1021/jacs.5c11534 ------------------------------------------------------------------------------------------------------------- Time Code 00:00 - Intro 00:18 - Structural Features 00:42 - Synthetic Challenges 01:06 - Retrosynthetic Analysis 01: 40 - Cyclobutane Construction Strategies 02:39 - Forward Synthesis 04:26 - Meinwald Rearrangement 05:12 - Conia-Ene Cyclization 05:38 - Reduction And Stereochemistry 06:03 - Birch Reduction 07:21 - Bond Isomerization 08:14 - MHAT Cyclization 10:17 - Rubottom Oxidation 10:53 - Mander’s Reagent 11:18 - Selenoxide Elimination 11:43 - Luche Reduction 12:20 - Barton–McCombie Deoxygenation