Psoriasis: Stress, Inflammation & the Gut-Brain Axis with Dr Rachel Wilson, PhD. скачать в хорошем качестве

Psoriasis: Stress, Inflammation & the Gut-Brain Axis with Dr Rachel Wilson, PhD.

Episode 16: Dr Rachel Wilson, PhD explores the current literature on the Gut-Brain Axis, Leaky Gut Theory and how chronic stress can lead to inflammation and affect all kinds of health conditions. She also tells us about her personal journey living with stress and psoriasis. Needless to say, it was a very interesting conversation. *Keep in mind that the content of this interview is for information purposes only and does NOT constitute medical advice. Please consult your medical doctor prior to attempting anything mentioned in this interview. Thank you!* About Dr. Rachel Wilson: B.S. in Molecular & Cellular Biology; Undergraduate senior research thesis "The Kinetics & Substrate Specificity of the Lanthipeptide Peptidase ElxP" Ph.D. in Microbiology & Cell Science; Dissertation "Bioprecipitation: The Connection Between Microbiology & Meteorology" Postdoctoral Research Position: Scientist at Handix Scientific, studied airborne distribution of SARS-CoV-2, helped develop near-real-time air sampler for airborne viruses and bacteria Current Position: Science writer on current research topics relating to psoriasis, gut-brain-skin axis, human microbiome, and earth microbiome. Outline: 00:00 Intro 01:48 Dr Wilson's academic and personal journey living with Psoriasis 08:55 The Gut-Brain Axis and Leaky Gut Theory - What the Research suggests 13:10 What I find interesting clinically as a Doctor of Chiropractic 16:05 Improving the skin = Improving overall Health - a Holistic perspective 23:09 The importance of Stress Management 25:42 Stress has a Cumulative Effect 27:48 Everybody is under a UNIQUE combination of stressors 30:48 Early life stress/trauma 32:41 Healing is a JOURNEY 37:50 The importance of an individualized approach 42:38 THE ONE THING listeners should take away from our interview 47:02 Conclusion and contact information References and 35+ articles (full document download): https://485b6d9b-83ac-44da-b110-94ac8... References: Leaky gut syndrome 1. Paray, B.A., Albeshr, M.F., Jan, A.T. and Rather, I.A., 2020. Leaky gut and autoimmunity: an intricate balance in individuals health and the diseased state. International journal of molecular sciences, 21(24), p.9770. 2. Mu Q., Kirby J., Reilly C.M., Luo X.M. Leaky gut as a danger signal for autoimmune diseases. Front. Immunol. 2017;8:598. doi: 10.3389/fimmu.2017.00598. 3. Fasano A. Zonulin and its regulation of intestinal barrier function: The biological door to inflammation, autoimmunity, and cancer. Physiol. Rev. 2011;91:151–175. doi: 10.1152/physrev.00003.2008. Connections between psoriasis, inflammation, leaky gut, gut microbial dysbiosis 1. Identification of bacterial DNA in the peripheral blood of patients with active psoriasis. Ramirez-Bosca et al 2015. JAMA dermatology. Doi: 10.1001/jamadermatol.2014.5585 2. Psoriasis and gut microbiome—current state of art. Polak et al. 2021. International Journal of Molecular Sciences. Doi: https://doi.org/10.3390/ijms22094529 3. Gut microbial composition in patients with psoriasis. Codoner et al 2018. Scientific reports. Doi: https://doi.org/10.1038/s41598-018-22... 4. Intestinal barrier integrity in patients with plaque psoriasis. Sikora et al. 2018. Journal of dermatology. Doi: https://doi.org/10.1111/1346-8138.14647 5. Association of psoriasis with inflammatory bowel disease: a systemic review and meta-analysis. Fu et. Al. 2018. JAMA dermatology. Doi: 10.1001/jamadermatol.2018.3631 Gut-Brain-Skin Axis (and cross-talk between gut microbes and CNS) 1. Appleton J. The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health. Integr Med (Encinitas). 2018 Aug;17(4):28-32. PMID: 31043907; PMCID: PMC6469458. 2. Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015;28(2):203-209. 3. Mayer EA, Savidge T, Shulman RJ. Brain-gut microbiome interactions and functional bowel disorders. Gastroenterology. 2014;146:1500-1512. 4. Mayer EA. Gut feelings: The emerging biology of gut-brain communication. Nat Rev Neurosci. 2011;12:453-466. 5. Moloney RD, Desbonnet L, Clarke G, et al. The microbiome: stress, health and disease. Mamm Genome. 2014;25(1-2):49-74. Psoriasis, depression, mood disorders, dysregulated nervous system 1. Psoriasis, Depression, and Suicidality. Nicholas and Gooderman 2017. Skin Therapy Letter. PMID: 28486717 2. Depression and suicidality in psoriasis: review of the literature including the cytokine theory of depression. Koo et al 2017. Doi: https://doi.org/10.1111/jdv.14460 3. Assessing and Improving Psychological Well-Being in Psoriasis: Considerations for the Clinician. Blackstone et al 2022. Psoriasis: Targets and Therapy. Doi: 10.2147/PTT.S328447