The beginner's guide to morphological profiling (Morphological profiling, part 1) скачать в хорошем качестве

The beginner's guide to morphological profiling (Morphological profiling, part 1)

An introduction to the ideas of morphological profiling, as well as exactly what data we use to do it (and why). If you want to better understand how this is done in practice, please watch part 2 at    • Practical exploration of morphological pro...   Helpful links (for both videos): The written tutorial, including all the data shown in parts 1 and 2 - https://github.com/broadinstitute/BBB... How to determine if your segmentation is "good enough" - https://carpenter-singh-lab.broadinst... A blog post on considerations of normalization - https://carpenter-singh-lab.broadinst... The CellPainting protocol - https://www.biorxiv.org/content/10.11... A multi-lab paper describing morphological profiling methods - https://www.nature.com/articles/nmeth... The "Dinosaurus Dozen", aka why you should always directly examine your data in addition to doing high-level exploration in tools like this - https://www.autodesk.com/research/pub... An introduction to t-SNE clustering (video 2) https://en.wikipedia.org/wiki/T-distr... The original paper describing the data set used in both videos - https://slas-discovery.org/article/S2... The paper describing Cell Painting discovering novel pathway biology (video 1) - https://elifesciences.org/articles/24060 A recent review on what Cell Painting and other phenotypic drug discovery methods can do - https://www.nature.com/articles/s4157...