H&N E19: HPV Negative Oropharynx, Unknown Primary, and Salvage Strategies скачать в хорошем качестве

H&N E19: HPV Negative Oropharynx, Unknown Primary, and Salvage Strategies

Today is the curveball episode. Boards love these scenarios because they test judgment, sequencing, and restraint. We will do three things. First, we will contrast the tobacco-associated, p16-negative oropharynx patient with the favorable HPV-positive population, because there is no de-escalation lane here. Second, we will develop a clean, board-safe, and unknown primary workup that escalates logically and efficiently — ultimately leading to the modern transoral diagnostic step, which can localize the primary at high rates. Third, we will walk through salvage strategy selection in previously irradiated patients — who to push, who to spare, and how to talk about it.