The Types Of B12 And Benefits скачать в хорошем качестве

The Types Of B12 And Benefits

Are you looking at the different types of B12 and wondering which one you should take? What's the difference between hydroxymethyl, adenosyl, and cobalamin? And how do I know which one I need to take? My name's Dr. Terranella, and in this video, we're going to look at that question. We'll go into the different types of B12 and when you might think about using each one. So in this video, we're going to look at some of the different types of vitamin B12. Vitamin B12 is also known as cobalamin, and it's a complex molecule that plays a critical role in various physiological processes in our body, including: Production of red blood cells, Production of DNA in general and the overall maintenance of our nervous system and myelin sheath. Some of these different roles of vitamin B12 are supported by the different forms of B12 that are available. To understand the different types or forms of B12, we first want to look at the overall structure of vitamin B12. The structure of B12 actually has a lot of similarities with hemoglobin. These similarities between hemoglobin and B12 arise from the presence of a ring-like structure in the vitamin B12 molecule. This ring-like structure is similar to the heme molecule that's present in hemoglobin. Hemoglobin, if you don't know, is the molecule in a red blood cell responsible for transporting oxygen throughout the blood. In the middle of the heme molecule is an iron molecule. So, B12 also has a ring-like structure, but it's slightly different. Instead of a porphyrin ring, it's a corrin ring. But the middle part is similar in that it's a cobalt molecule in the center of that ring. All that to point out that the molecule of B12 is held together through electromagnetism. So you have positive and negative charges that allow these things to fit together. You have that cobalamin molecule, and then once it has one of these functional groups attached to it, like a hydroxyethyl molecule, it's no longer magnetically charged. It's more of a neutral charge. So these other types of molecules bind to that B12 in order to make it more neutral. So those functional groups can be a methyl group, an adenosyl group, a hydroxy group, and then sometimes you'll get a cyanide group. That's not really a functional group in terms of having some sort of utility in our body. Really, that's just a more stable way to deliver the cobalamin molecule. So, we have a methyl group which forms methylcobalamin. We have an adenosyl group which forms adenosylcobalamin, and a hydroxy group, which forms hydroxycobalamin, and then cyano, which forms cyanocobalamin. So those create the different forms of B12, which are important for the various functions of B12. As I said, cyanocobalamin is not really functional. It just forms a really stable molecule, and that's why it's very cheap to make and also the most commonly used commercially available form. You're going to find it in a lot of supplements, but there is some concern about the cyanide group that's in there. Cyanide is a poisonous substance that poisons our mitochondria. If you don't have to, I would recommend not using that form. It is still going to provide cobalamin, and our bodies probably can get rid of that cyanide pretty efficiently. But if you have any concerns about cyanide, I would recommend using a different form of B12, such as methylcobalamin or adenosylcobalamin. If you want to check that out, it's available on the YouTube channel. So let's go on to methylcobalamin now. So methylcobalamin is the more active form that is used in the methionine or methylation cycle, and it's used to recycle folate and allow homocysteine to turn into methionine, which then can be used to make S-adenosylmethionine (SAMe) and produce a functional methyl donor. So this form of B12 is going to be a little bit more stimulating to the mind and to the body. And so it's helpful for people with depression and fatigue when they're deficient to provide methylcobalamin. However, in some people that may feel a little more anxious or overall stimulated, they may not want to use this form. Adenosylcobalamin is a less common form of B12 that's used in the mitochondria and nervous system. The adenosyl part can be used to make adenosine, which is part of adenosine triphosphate (ATP). But one of the key aspects of adenosylcobalamin is its involvement in the methyl-CoA to CoA process. When you don't have enough B12, in particular adenosyl B12, you get a buildup of methylmalonic acid and that can damage and interfere with nerve signal transmission, cause numbness, tingling, and different nervous system disorders. That's also why a lot of people with B12 deficiency will present that way. That form of B12 is less stable, and that's part of the reason why it is more expensive to produce and make. It's often combined with hydroxycobalamin.