PNAS 2019 Cozzarelli Prize Winner for Class II: Biological Sciences скачать в хорошем качестве

PNAS 2019 Cozzarelli Prize Winner for Class II: Biological Sciences

Mosaic origin of the eukaryotic kinetochore Eelco C. Tromer, Jolien J. E. van Hooff, Geert J. P. L. Kops, and Berend Snel When eukaryotic cells evolved from prokaryotic ancestors, they vastly increased in complexity. How many of the typical eukaryotic features emerged during this process remains unclear. Tromer, van Hooff, et al. reconstructed the origin of one such feature, the kinetochore, a large proteinaceous structure that drives separation of chromosomes during cell division. The authors found that the proteins that make up the kinetochore are of mosaic origin: Some have relatives in different eukaryotic or prokaryotic cellular processes, whereas others are unique to the kinetochore. Nevertheless, many kinetochore proteins share part of their evolutionary trajectories, arising from ancient gene duplications within the kinetochore. The results suggest that the kinetochore originated by recruiting proteins globally and expanded by duplicating them locally, characterizing one of the modes by which key eukaryotic systems evolved. Read the award-winning research article: https://www.pnas.org/content/116/26/1...