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UK CEiRSI In Silico Regulatory Airlock Panel Session: In-device integration of treatment data and models for optimised radiotherapy performance About UK CEiRSI: The UK’s first Centre of Excellence in In-Silico Regulatory Science and Innovation (UK CEiRSI) advances computational evidence in healthcare, bringing together academia, industry, and regulators to shape global standards. About the In Silico Regulatory Airlock Panel Sessions: These sessions bring together individuals from academia, industry, and regulatory bodies, to examine the practical strengths and weaknesses of existing international credibility frameworks. Each Case Study Panel Session will focus on a hypothetical medical intervention (drug or device) that will enable us to interrogate and refine current standards and frameworks for the credibility assessment of model-informed evidence. About this Case Study: Aim: To establish credibility recommendations for in-silico models in radiotherapy by evaluating whether integrating treatment data, device logs, imaging, and radiobiology models can predict the impact of device variations on patient safety, as measured by tumour control probability and normal tissue complication probability, to inform quality assurance and regulatory compliance. Agenda: Rationale for the use of in-silico radiobiology models for radiotherapy treatment systems Panel credibility recommendations for the credibility assessment of in-silico radiobiology models Panel and audience Q&A Case Study Leads: Dr Tuathan O’Shea, Varian David Grainger, MHRA Prof Derek Hill, University College London Connect with the UK CEiRSI Community: Our LinkedIn Hub: / 105821448 Our Eventbrite Page: https://www.eventbrite.co.uk/o/uk-cei... Our YouTube Channel: / @uk-ceirsi Connect with the InSilico UK Community: Our Webpage: https://www.insilicouk.org Our Publications: https://zenodo.org/communities/insili... Our Podcast: https://www.insilicouk.podbean.com Our LinkedIn Group: / 9169266