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UK CEiRSI In Silico Regulatory Airlock Panel Session: Deep Brain Stimulation: Establishing Credibility Recommendations for In Silico Trials About UK CEiRSI: The UK’s first Centre of Excellence in In-Silico Regulatory Science and Innovation (UK CEiRSI) advances computational evidence in healthcare, bringing together academia, industry, and regulators to shape global standards. About the In Silico Regulatory Airlock Panel Sessions: These sessions bring together individuals from academia, industry, and regulatory bodies, to examine the practical strengths and weaknesses of existing international credibility frameworks. Each Case Study Panel Session will focus on a hypothetical medical intervention (drug or device) that will enable us to interrogate and refine current standards and frameworks for the credibility assessment of model-informed evidence. About this Case Study: Aim: To establish credibility recommendations for in-silico models in developing and testing physiologically controlled Deep Brain Stimulation (DBS) algorithms by assessing whether the device’s efficacy is resistant to algorithm failure under worst-case fluctuations in the control physiomarker. Agenda: Rationale for the use of in-silico models for developing and testing physiologically controlled Deep Brain Stimulation algorithms Panel credibility recommendations for the credibility assessment of Deep Brain Stimulation algorithms Panel and audience Q&A Case Study Leads: Moaad Benjaber, Amber Therapeutics Prof Tim Denison, University of Oxford Connect with the UK CEiRSI Community: Our LinkedIn Hub: / 105821448 Our Eventbrite Page: https://www.eventbrite.co.uk/o/uk-cei... Our YouTube Channel: / @uk-ceirsi Connect with the InSilico UK Community: Our Webpage: https://www.insilicouk.org Our Publications: https://zenodo.org/communities/insili... Our Podcast: https://www.insilicouk.podbean.com Our LinkedIn Group: / 9169266