Inflammation Derails Brain Homeostasis | Dr. Theoharis Theoharides | INIM Conference 2024 скачать в хорошем качестве

Inflammation Derails Brain Homeostasis | Dr. Theoharis Theoharides | INIM Conference 2024

In the recent INIM conference held on May 10, 2024, Dr. Theoharis Theoharides discussed his study on how inflammation derails brain homeostasis. Considering that no single cell type can help understand what’s happening in the brain, he uses a “brain on a chip” to mimic what’s happening in the brain. In his presentation, he discussed the possibility of inflammation in the hypothalamus, which can be caused by many factors, including stress. He also highlighted the role of mast cells, the first cells activated when danger is sensed, and how triggering them affects every organ of the body, which is characteristic of Mast Cell Activation Syndrome (MCAS). The study proves the capability to reduce fatigue and increase cognition and the possibility of helping brain health through proper supplementation. Timestamps: 00:00 Introduction 07:01 Immune triggers regulate the hypothalamus 08:48 The effect of stress 09:34 What are mast cells? 11:44 How mast cells sense activity in the lumen 13:58 New mast cell receptors 15:54 What happens inside the hypothalamus 17:12 Why stress affects everything 18:31 Molds is a mast cell trigger 20:57 What is mast cell activation syndrome? 23:22 Mast cells, neurons, and the microglia 25:44 COVID-19 and Long COVID 29:22 What are flavonoids? 29:49 Drugs that are mast cell inhibitors 31:35 Relevance to homeostasis 33:14 Helpful dietary supplements for MCAS 35:07 Research findings Dr. Theoharis Theoharides is a Professor, Vice Chair of Clinical Immunology, and Director at the Institute for Neuro-Immune Medicine-Clearwater, an Adjunct Professor of Immunology at Tufts School of Medicine, where he was a Professor of Pharmacology and Internal Medicine, and also the Director of Molecular Immunopharmacology & Drug Discovery, and Clinical Pharmacologist at the Massachusetts Drug Formulary Commission (1983-2022). He received his BA, MS, MPhil, PhD, and MD degrees and the Winternitz Price in Pathology from Yale University and received a Certificate in Global Leadership from Tufts Fletcher School of Law and Diplomacy and a Fellowship at Harvard Kennedy School of Government. He trained in internal medicine at New England Medical Center, which awarded him the Oliver Smith Award, “recognizing excellence, compassion, and service.” Dr. Theoharides has 485 publications (46,491 citations; h-index 106), placing him in the world’s top 2% of most cited authors, and he was rated the worldwide expert on mast cells by Expertscape. He was inducted into the Alpha Omega Alpha National Medical Honor Society, the Rare Diseases Hall of Fame, and the World Academy of Sciences. Website: https://www.drtheoharides.com LinkedIn: linkedin.com/in/theoharis-theoharides-ms-phd-md-faaaai-67123735 #inflammation #mastcells #MCAS #mastcellactivationsyndrome