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Nephrotic and Nephritic Syndrome | Causes Symptoms & Treatment🩺 8 years ago

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Nephrotic and Nephritic Syndrome | Causes Symptoms & Treatment🩺

#NephroticSyndrome #NephriticSyndrome #Nephrology Nephrotic and Nephritic Syndrome | Causes Symptoms & Treatment🩺 Like this video? Sign up now on our website at https://www.DrNajeebLectures.com to access 800+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $99 ONLY! Sign up now on our website at https://members.drnajeeblectures.com/... --------------------------------------------------------------------------------------------------------------------------- Why sign up for premium membership? Here's why! Membership Features for premium website members. 1. More than 800+ Medical Lectures. 2. Basic Medical Sciences & Clinical Medicine. 3. Mobile-friendly interface with android and iOS apps. 4. English subtitles and new videos every week. 5. Download option for offline video playback. 6. Fanatic customer support and that's 24/7. 7. Fast video playback option to learn faster. 8. Trusted by over 2M+ students in 190 countries. --------------------------------------------------------------------------------------------------------------------------- ▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬ 00:00:00 Glomerulopathies 00:00:56 Basic Structure Of Glomerulus 00:10:00 Grade I Injury 00:11:40 Grade Ii Injury 00:12:49 Grade Iii Injury 00:15:36 Liver Role 00:18:30 Clinical Manifestations Of Glomerular Injury 00:24:45 Anasarca 00:26:29 Why Edema Is More In Preorbital Area 00:28:00 Concept About Pitting And Non Pitting Edema 00:39:01 Activation Of Renin Angiotensin Aldosterone System 00:41:50 Adh Effect 00:42:53 Triangle Of Clinical Features 00:43:43 Hyperlipidemia 00:48:30 Nephrotic Syndrome 00:54:13 Thrombus Formation 00:56:26 More Chances Of Infections 00:58:02 Nephritic Syndrome And Mechanism 01:13:25 Recap 01:14:14 Differences In All The Glomerular Injuries 01:27:13 Chronic Renal Failure --------------------------------------------------------------------------------------------------------------------------- Nephrotic & Nephritic Syndrome-Causes, Symptoms & Treatment-Nephrology Basic anatomy of a Glomeruli; Fenestrated Endothelial cells, Filtrations slits; Significance of these structures as size barriers, charge barriers; Albumin. Injury to Glomeruli; Albuminuria, Explanation of terms: Selective Proteinuria & Non-selective Proteinuria. Proteinuria less than 3.5gm/day; Catabolism of large number of proteins in PCT before they end up as Proteinuria; Hypoalbuminemia. Consequence of Hypoproteinemia (mainly hypoalbuminemia); Reduced Osmotic Pressure, Severe Generalized Edema [Anasarca], Periorbital edema. Pitting and Non-pitting edema; Oncotic and Osmotic Pressures; Clinical Implications; Breast Cancer; lymphatics involved or not. Heavy Proteinuria (Hypoproteinemia); Significance of decreased blood volume & resulting low renal perfusion; activation of RAAA; salt-water retention; Hyperosmolar blood, Release of ADH; causing further retention: Triangle of Heavy Proteinuria, Hypoproteinemia and Generalized Edema. Liver: Increased Lipoprotein synthesis resulting in Hyperlipidemia/Dyslipidemia; Lipidurea; Defining Nephrotic Syndrome; Nephrotic & Sub-nephrotic Range Proteinuria. Additional protein losses through urine: Transferrin loss in long term/chronic proteinuria; Iron Deficiency Anemia. Antithrombin-3 loss; Procoagulant blood (Increased Thrombotic tendency). Complement loss in proteins; weakened immune system; increased susceptibility to pneumococcal infections. Nephritic Syndrome: Advanced injury to Glomeruli; Leakage of all types of proteins, even RBCs; Hematuria (of glomerular origin) Dysmorphic star shaped RBCs, Cylindrical RBC casts Nephritic Syndrome continued: Inflamed, clogged glomeruli; Decreased Renal Blood Flow, Reduced GFR; Oliguria. Proteinuria paradoxically decreased; clinical; need to differentiate from an improving Nephrotic Syndrome. Nephritic Syndrome continued: Urea, Creatinine levels rise; Azotemia. Powerful stimulation of RAAA axis; Hypertension. Triangle of Hematuria, Oliguria and Hypertension. Recap. Rapidly Progressive Glomerulonephritis/Crescent Glomerulonephritis: Very intense injury to Glomerular Membrane: Fibrin leaks; Macrophages arrive, Growth Factors released, proliferating epithelial cells & macrophages; Cellular Crescents. Clinical features of (Acute) Renal Failure develop; High K; Arrhythmia, Uremic pericarditis & encephalopathies. --------------------------------------------------------------------------------------------------------------------------- Join this channel to get access to perks: Sign up now on our website at https://members.drnajeeblectures.com/...    / @doctornajeeb   Follow us on Facebook :-   / drnajeeb   Follow us on Instagram :-   / drnajeeblectures  

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