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The Science of Fasting: How Fasting Actually Works #video The "Survival Switch" is real—you just need to know how to flip it. In this clinical masterclass, Dr. YK breaks down the exact biochemistry of what happens to your body when you stop eating. We move past the surface-level talk and dive into the "Gold Standard" of fasting science—from the moment your insulin drops to the 500% spike in Growth Hormone that protects your muscles. What you’ll learn in this 9-minute deep dive: The 12-Hour Crossroads: Why hunger is actually a sign of metabolic success. The Brain Fog Solution: How Ketones act as "High-Octane Fuel" for your mind. Autophagy & The Nobel Prize: The cellular "Spring Cleaning" process that renovates your body. The First Bite: Why how you BREAK your fast is more important than the fast itself. The 12-Hour Crossroads (1:30): Initially, your body burns glucose (sugar) stored as glycogen. After about 12 hours, this "sugar tank" is empty, leading to hunger. This hunger signifies a metabolic shift, as your body is forced to seek alternative fuel sources. • Transition to Fat Burning (Lipolysis) & Ketogenesis (2:45): Once glycogen is depleted and insulin levels drop, hormone-sensitive lipase (HSL) is activated, releasing stored fat for energy. Your liver then converts these fats into ketones, which are a "high-octane" fuel for your brain, clearing brain fog (3:03). • Autophagy and Cellular Repair (4:45): Around 16 hours of fasting, an energy sensor called AMPK is activated, silencing a growth pathway called mTOR. This triggers autophagy, a cellular "spring cleaning" process where the body recycles damaged components and builds new, stronger cells. This discovery won a Nobel Prize in 2016. • Muscle Protection via Growth Hormone (7:15): A common concern about fasting is muscle loss, but the video explains that when insulin levels drop, growth hormone spikes by 500%, acting as a "bodyguard" to muscles, ensuring fat is burned while muscles are preserved. • Breaking the Fast (Refeeding) (8:00): The video emphasizes that how you break your fast is crucial. After 16-18 hours, your body's insulin sensitivity is at its peak. Breaking the fast with carbohydrates can cause a massive insulin spike and metabolic shock. It's recommended to start with a small bowl of bone broth (for non-vegetarians) or lime/cumin water (for vegetarians), followed by healthy fats and proteins to maintain a stable repair mode and slow down sugar absorption. 🕒 TIMESTAMPS 0:00 - The Evolutionary Switch: Why we aren't built for constant nutrition 1:30 - Draining the Battery: The first 12 hours and Glycogen depletion 2:45 - The Crossroads: Transitioning from Sugar to Fat burning (Lipolysis) 3:15 - The Liver’s Lab: Ketogenesis and the end of Brain Fog 4:45 - The Deep Clean: Understanding Autophagy (2016 Nobel Prize) 7:15 - Saving the Engine: Why Growth Hormone spikes by 500% 8:00 - The Art of Refeeding: How to break your fast without a crash 8:30 - Conclusion: Flipping your metabolic switch SCIENTIFIC KEYWORDS MENTIONED Enzymes: Hormone-Sensitive Lipase (HSL), Lysosomal Acidic Enzymes. Pathways: Beta-Oxidation, AMPK (Energy Sensor), mTOR (Growth Sensor). Processes: Lipolysis, Ketogenesis, Autophagy, Apoptosis. #video #videofeed #viralvideo #foodie #Fasting #Autophagy #Biohacking #IntermittentFasting #DrYK #MetabolicHealth #NutritionScience #ramadan #iftar #FastingScience #Autophagy #IntermittentFasting #HealthOptimization #Biohacking #WeightLossScience #Metabolism