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Natamycin In Shredded Cheese

Based on the available data, the Committee concluded that there is no concern for the induction of antimicrobial resistance and that the risk of natamycin having a disrupting effect on the microbiome of the human GIT is low. The Committee re-affirmed the ADI of 0-0.3 mg/kg bw for natamycin established by the previous Committee at its Twentieth meeting. The Committee further noted that the NOAELs in the new 13-week and 1-year studies in rats (42 and 26 mg/kg bw per day, respectively), with the application of a 100-fold uncertainty factor, support the current ADI of 0-0.3 mg/kg bw. The Committee noted that dietary exposure estimates for natamycin of up to 0.25 mg/kg bw per day for all population subgroups assessed were below the ADI, and concluded that dietary exposure to natamycin was not of toxicological concern. https://www.who.int/publications/i/item/ 9789240100978