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Apply to join Foresight Biotech & Health Extension program: https://foresight.org/biotech-health-... A group of scientists, entrepreneurs, funders, and institutional allies who cooperate to advance biotechnology to reverse aging and extend human healthspan. This group is sponsored by 100 Plus Capital. http://100pluscap.com/ Foresights Personal Longevity Group Exploring anti-aging methods, monthly virtual meetings, expert discussions, private group for Foresight Patrons. https://foresight.org/personal-longev... Brad Younggren | Therapeutic Plasma Exchange (TPE): A Tool Against Aging and Disease Bio: Brad Younggren, MD, is CEO and co-founder of Circulate Health, a company dedicated to extending human healthspan. A former U.S. Army physician, Dr. Younggren served as a combat physician in Iraq and was awarded a Bronze Star and Combat Medical Badge. An emergency medicine specialist and seasoned healthcare executive, Younggren has led teams at the cutting edge of medicine for decades. Most recently, he was President and Chief Medical Officer at 98point6, where he led the development and launch of AI-powered primary care solutions. He previously served as CMO at Cue Health, Shift Labs, and Mobisante. At Circulate, Younggren leads an expert team of clinicians and scientists working to harness the potential of therapeutic plasma exchange to advance health and longevity. https://www.circulate.health/ Abstract: Aging is the primary risk factor for most chronic diseases, driving over 90% of U.S. healthcare expenditures. However, emerging science suggests that aging itself can be targeted as a modifiable process. Therapeutic Plasma Exchange (TPE) is a promising intervention that removes harmful substances from the bloodstream, reducing inflammation, disease burden, and potentially reversing aspects of biological aging. Circulate Health is pioneering this space, with clinical trial data demonstrating measurable reductions in biological age and improvements in key biomarkers. Beyond its longevity benefits, recent findings suggest TPE may help reduce microplastics and other environmental toxins—offering a practical, scalable approach to mitigating modern health threats. In this talk, we’ll explore the science behind TPE, its clinical applications, and why Circulate Health’s model makes this groundbreaking treatment accessible to more patients and clinics. Timecodes 00:00 Introduction and Speaker Background 00:55 Overview of Plasma Exchange and Research Goals 02:17 Circulate Health's Approach and Operations 07:12 Therapeutic Plasma Exchange: Mechanism and Benefits 17:06 Research Findings and Biological Age Reduction 24:17 Future Research and Applications 30:50 Q&A Session 31:55 Plasma Exchange Pre-Testing and Qualifications 32:22 Plasma Donation and Safety Protocols 33:04 Plasma Exchange vs. Blood Donation 33:50 Exploring Plasma Exchange Protocols 34:58 Addressing Plasma Exchange Questions 35:48 Sham Control Group and Biological Age 38:04 Technological Innovations in Plasma Exchange 41:35 Cost and Accessibility of Plasma Exchange 45:20 Future of Plasma Exchange and Reimbursement 47:05 Study Results and Further Research 53:40 Concluding Remarks and Contact Information ══════════════════════════════════════ About The Foresight Institute The Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1986 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support. From molecular nanotechnology, to brain-computer interfaces, space exploration, cryptocommerce, and AI, Foresight gathers leading minds to advance research and accelerate progress toward flourishing futures. We are entirely funded by your donations. If you enjoy what we do please consider donating through our donation page: https://foresight.org/donate/ Visit https://foresight.org, subscribe to our channel for more videos or join us here: • Twitter: / foresightinst • Facebook: / foresightinst • LinkedIn: / foresight-institute