Anticoagulants Concept for NEET/AIIMS/USMLE/FMGE/PLAB скачать в хорошем качестве

Anticoagulants Concept for NEET/AIIMS/USMLE/FMGE/PLAB

Anticoagulants Concept for NEET/AIIMS/USMLE/FMGE/PLAB • In the extrinsic coagulation pathway, tissue injury releases tissue factor, which along with factor VIIa and calcium converts factor X to Xa. • Factor Xa along with Va and calcium converts prothrombin (II) to thrombin (IIa). • Thrombin converts fibrinogen to fibrin which forms the permanent clot. • Antithrombin III is a protease that breaks down factors IIa, IXa, Xa, XIa and XIIa. • Thus, one way of achieving anticoagulant effect is by inhibiting coagulation pathway at the level of thrombin by giving direct thrombin inhibitors like lepirudin. • Another way is to stimulate anticoagulation pathway by activating antithrombin III by giving indirect thrombin inhibitors like heparin. Heparin and LMWH can cause heparin induced thrombocytopenia, whereas fondaparinux can be used for treatment of heparin induced thrombocytopenia.