Glycopeptide Antibiotic Vancomycin Concept for NEET/AIIMS/USMLE/FMGE/PLAB скачать в хорошем качестве

Glycopeptide Antibiotic Vancomycin Concept for NEET/AIIMS/USMLE/FMGE/PLAB

Glycopeptide Antibiotic Vancomycin Concept for NEET/AIIMS/USMLE/FMGE/PLAB Glycopeptides: • This class contains the most commonly used drug vancomycin and others like teicoplanin, dalbavancin, telavancin and oritavancin. • Glycopeptides inhibit d-alanine because of which peptide bond cannot be formed with glycine and crosslinking is inhibited. • They have a large molecular size and hence have poor oral absorption and poor penetration through capsule of gram negatives. Thus, these are used only for gram positive organisms. Vancomycin • Intravenous vancomycin is the drug of choice for treatment of systemic MRSA infection (sepsis and endocarditis), enterococcus faecium and ampicillin resistant enterococcus faecalis. • Oral vancomycin is drug of choice for treatment of pseudomembranous enterocolitis. • Vancomycin can cause nephrotoxicity and ototoxicity. It stimulates histamine release, which causes vasodilation, flushing and a red discoloration of patient known as red man syndrome.