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Do artificial sweeteners help us cut calories and lose weight? Are they safe? A look at Splenda, Sweet´n Low, Equal, Stevia and other artificial, low-calorie or no-calorie sweeteners. Are they healthier than regular sugar? Are they more effective? Is one brand better? A new study looked at health consequences of consuming artificial sweeteners. They focused on soda which is the #1 source of added sugars in many western countries. Prior studies found people who consume more diet soda tend to have higher risk of weight gain, diabetes, cardiovascular disease, even risk of dying. This doesn’t tell us if drinking diet soda causes these problems. People most likely to consume a lot of diet soda are the ones worried about their weight, who are already obese, with a history of struggling with weight. The new analysis tries to increase chance of looking at actual effect of diet soda on health. Looked diet soda vs regular soda, water vs regular soda and diet soda vs water. Diet soda outperformed regular soda. Lower body weight, BMI, risk of death Water outperformed regular soda. Lower body weight, body fat, BMI, risk of diabetes water vs diet soda, they didn’t find any significant differences in body weight, BMI, diabetes, stroke meta of RCTs found sweetners helped reduce weight/BMI compared to regular sugar. one found sweetners reduced energy intake compared to regular sucrose and reduced BMI Do they raise glucose or cholesterol? In that same trial there was no significant effect of sweetners on HbA1c, insulin resistance, cholesterol or triglycerides another one looked at stevia. it reduced diastolic blood pressure and fasting glucose. no significant effect on blood lipids, cholesterol and triglycerides one looked at saccharin (Sweet n low). no effect on glucose metabolism. glucose and insulin response to a meal unchanged one saw no effect of sweeteners on triglycerides or cholesterol; In ppl with normal LDL-cholesterol, small increase sucralose (Splenda): no change in fasting glucose, HbA1c, insulin, triglycerides and cholesterol. postprandial glucose and insulin a little higher overall sweeteners help with weight loss compared to sugar artificial sweetners are extremely sweet, hundreds of times sweeter than sugar. aspartame is 200x sweeter than sugar and Sucralose in Splenda is 600 times sweeter than regular sugar. Stevia is intermediate, 200-400x sweeter 1 study: artificial sweeteners, especially aspartame and acesulfame-K, associated with cancer study: changes in microbiome of mice taking artificial sweeteners. saccharin in humans changed microbiome. larger trial: saccharin did not change microbiome if sweetners help cut back on sugar, data indicates Sweeteners trump sugar. cut back on artificial sweetners? avoid relapse to sugar. better off with artificial sweetner Connect with me: Facebook: / drgilcarvalho Twitter: / nutritionmades3 Animations: Even Topland @toplandmedia References: https://diabetesjournals.org/care/art... https://onlinelibrary.wiley.com/doi/p... https://link.springer.com/article/10.... https://www.nature.com/articles/s4136... https://academic.oup.com/eurjpc/artic... https://microbiomejournal.biomedcentr... https://www.mdpi.com/2076-2607/10/2/4... https://journals.plos.org/plosmedicin... https://www.fda.gov/food/food-additiv... https://www.nhs.uk/conditions/phenylk... https://pubmed.ncbi.nlm.nih.gov/23909... https://journals.plos.org/Plosmedicin... https://www.sciencedirect.com/science... https://www.nature.com/articles/natur... https://microbiomejournal.biomedcentr... https://www.mdpi.com/2076-2607/10/2/4... Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!. #NutritionMadeSimple #GilCarvalho 0:00 Introduction 0:44 Prior concerns with Artificial Sweeteners 2:34 New study 3:53 Uncertainty in science 4:32 Randomized trials 7:34 Funding 10:49 Animal data 11:35 Specific conditions 11:58 Artificial Sweeteners & Cancer 12:42 Artificial Sweeteners & the microbiome 14:02 The bottomline 16:17 Practical strategies