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Vascular disorders comprise a broad spectrum of arterial and venous conditions that fundamentally alter blood flow within the systemic circulation. Arterial diseases, such as atherosclerosis and peripheral artery disease (PAD), primarily result in tissue ischemia by reducing the delivery of oxygen and nutrients. Conversely, venous diseases, including deep vein thrombosis (DVT) and chronic venous insufficiency (CVI), impair the return of blood and the removal of metabolic waste, leading to congestion and edema. Critical takeaways from this analysis include: • Atherosclerosis remains the leading cause of death in Western nations, serving as the underlying pathology for myocardial infarction, stroke, and PAD. • Aortic Dissection and Aneurysms represent high-risk structural failures; rupture risk for aneurysms increases significantly once the diameter exceeds 5 cm. • Acute Arterial Occlusion is a medical emergency characterized by the "7 Ps," typically caused by emboli. • Venous Thromboembolism (VTE), specifically the progression from DVT to Pulmonary Embolism (PE), represents a major cause of in-hospital mortality due to right ventricular strain and potential circulatory shock. • Inflammation and Structural Weakening are the unifying themes across these pathologies, whether manifested as vasculitis, plaque formation, or valvular incompetence.