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Francis Crick Lecture 2018 delivered by Dr Miratul Muqit: Parkinson’s disease: decoding the mysteries of neurodegeneration Parkinson’s disease has emerged as a leading cause of brain degeneration in aged populations across the world. Patients typically develop a progressive disturbance of movement due to the selective loss of dopamine-containing neurons in the brain. The mechanisms for why these brain cells die have remained mysterious, hampering efforts to develop diagnostic tests and effective therapies that can slow the disease. In this talk, Professor Miratul Muqit discussed how genetic and biochemical discoveries are transforming our understanding of the biological basis of Parkinson’s. This has elaborated key signalling pathways that when disrupted in neurons lead to disease onset and progression. Professor Muqit discussed the potential application of this fundamental knowledge towards therapeutic strategies against Parkinson’s. The Royal Society is a Fellowship of many of the world's most eminent scientists and is the oldest scientific academy in continuous existence. Visit our website to learn more: https://royalsociety.org/ The Royal Society publishes leading science journals. Stay informed: https://royalsociety.org/journals/