FPWR Funded Project: Defining impaired neuronal architecture in the Snord116del mouse model for PWS скачать в хорошем качестве

FPWR Funded Project: Defining impaired neuronal architecture in the Snord116del mouse model for PWS

The cognitive impairment experienced by many individuals with PWS remains poorly understood. Pilot data obtained in our laboratory indicates that loss of expression of Snord116 results in a reduction in the branching and length of basal dendrites in pyramidal neurons in the cortex of 10-day old mice. In this project we will use Golgi-Cox impregnation and Sholl analysis to characterize the architecture of apical and basal dendrites of pyramidal neurons in the neocortex. This project will begin to address a major deficit in our understanding of PWS, delineating the mechanisms of cognitive impairment, and ultimately predicating therapeutic strategies for the alleviation of this distressing aspect of human PWS.