(23) Oxidative Phosphorylation & Its Mechanism | ATP Production Explained in Detail | Biochemistry скачать в хорошем качестве

(23) Oxidative Phosphorylation & Its Mechanism | ATP Production Explained in Detail | Biochemistry

Download the "Solution Pharmacy" Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Tests and other GPAT Materials - https://play.google.com/store/apps/de... For iOS devices: Download the Class Plus app and enter the ORG code NQILV when prompted. All other steps remain the same as for Android devices. 2. Oxidative phosphorylation: The process of synthesizing ATP from ADP and Pi coupled with the Electron transport chain is known as Oxidative Phosphorylation Three sites for oxidative phosphorylation 1. Oxidation of FMNH2 by Coenzyme Q 2. Oxidation of Cytochrome b by Cytochrome C1 3. Cytochome oxidase reaction Mechanism of Oxidative Phosphorylation There are three theories or hypothesis, explaining the formation of ATP through electron transport chain. 1.Chemical coupling hypothesis: Proposed by Edward Stater (1953) During electron transport in respiratory chain, a series of high energy intermediates are first formed which are utilized for ATP synthesis Drawback- Lack Experimental Evidence 2. Conformational coupling hypothesis (Rotary motor model for ATP generation) By Paul Bayel (1964) Hypothesis: The energy liberated from ETC brings a conformational change in the mitochondrial membrane proteins and FoF1ATPase which leads to ATP synthesis Chemiosmotic hypothesis By Peter Mitchell, widely accepted. It states that electron transport pumps H+ from the mitochondrial matrix across the inner mitochondrial membrane to the inter-membrane space, thereby the matrix becomes basic (low H+) and the inter-membrane space becomes acidic (High H+). Due to this osmotic difference (electrochemical proton gradient) the H diffuseS into the matrix through a pore in the F0F1 ATPase which provides the energy for the ATP synthesis. The electron transport chain is a series of proteins and organic molecules found in the inner membrane of the mitochondria. Electrons are passed from one member of the transport chain to another in a series of redox reactions. Energy released in these reactions is captured as a proton gradient, which is then used to make ATP in a process called chemiosmosis. Together, the electron transport chain and chemiosmosis make up oxidative phosphorylation. Get in touch with the solution by just clicking the following links- Facebook Group-   / solutionpharamcy   Mobile App - https://play.google.com/store/apps/de... New Channel (Pharmacy Dictionary)    / @pharmacydictionary   E-Mail for official and other work - [email protected] #solutionpharmacy #Pharmacologyclass #Pharmacognosyvideos #GPAT