132: The Hidden Power of Ketones: Fueling + Signaling with Dr. Ben Bikman скачать в хорошем качестве

132: The Hidden Power of Ketones: Fueling + Signaling with Dr. Ben Bikman

📢 Ask Dr. Bikman’s Digital Mind (multilingual): https://benbikman.com/ben-bikmans-dig... 📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com Topic: Ketones, particularly BHB, aren’t just backup fuel—they’re powerful signals that affect inflammation, gene expression, and mitochondrial function. This episode shows how BHB acts like a hormone to enhance metabolic health and cellular resilience. Summary: In this episode of the Metabolic Classroom, Dr. Bikman explores the remarkable role of beta-hydroxybutyrate (BHB), the most abundant ketone body, as both a metabolic fuel and a cellular signaling molecule. While traditionally seen as mere backup energy, BHB is now recognized as a potent agent that influences gene expression, reduces inflammation, and protects mitochondrial function. Ben unpacks the dual nature of BHB, describing how it activates specific receptors like GPR109A and FFAR3, modulates immune responses, and directly inhibits the NLRP3 inflammasome, a key player in chronic inflammation. He also highlights how BHB affects epigenetic regulation through HDAC inhibition, enhancing cellular resilience and antioxidant defenses. The lecture concludes by tying these pathways together to show how ketones—whether produced endogenously or taken as supplements—convey a coordinated biological signal of adaptation and protection. This shift in understanding elevates ketones from mere “backup fuel” to central players in metabolic health. References: For complete show notes and references, we invite you to become an Insider subscriber. You’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben after the lecture, unlimited access to Dr. Bikman’s Digital Mind, ad-free podcast episodes, show notes and references, and online, live Office Hours access with Ben. It also includes Ben’s Weekly Research Review Podcast. Learn more: https://www.benbikman.com Translation Notes: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) Also, Dr. Bikman’s Digital Mind can interact with you in many languages: https://benbikman.com/ben-bikmans-dig... In addition, our channel has access to YouTube’s innovative “auto-dubbing” feature. The process supports translations from English into many languages, with more to come. Click on the gear icon, then choose “Audio track” to access. (This availability is often delayed several weeks or more, so check back often.) Timestamps (approximate): 01:20 — Introduction: Ketones as Fuel and Signals 02:03 — Structure and Types of BHB 03:15 — Ketone Production and Circulation 04:45 — How BHB Is Metabolized 05:55 — BHB’s First Receptor: GPR109A 08:45 — GPR109A and Inflammation 10:23 — BHB’s Role in the Brain and Stroke 11:45 — Second Receptor: FFAR3 and Sympathetic Nervous System 12:55 — BHB and Cancer via FFAR3 14:00 — BHB and the NLRP3 Inflammasome 16:05 — BHB’s Mechanism of Inflammation Inhibition 17:25 — NLRP3 in Disease: Alzheimer’s, Gout, etc. 18:45 — BHB as an Epigenetic Modifier 20:45 — FOX03A, MT2, and Antioxidant Gene Expression 22:35 — Summary: BHB’s Mitochondrial and Anti-Inflammatory Benefits 24:15 — BHB in Clinical Application and Therapeutics 25:55 — Final Takeaway: BHB as a Master Signal NOTE: The information presented is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Dr. Bikman is not a clinician—and, he is not your doctor. Always seek the advice of your own qualified health providers with questions you may have regarding medical conditions. #Ketones #BHB #MetabolicHealth #DrBenBikman #InsulinResistance #NLRP3 #Inflammation #Mitochondria #HDAC #NutritionalKetosis #KetogenicDiet #ExogenousKetones #Fasting #Autophagy #AlzheimersPrevention #Epigenetics #CellularHealth #BenBikman #MitochondrialSupport #LowCarbScience #KetoneScience Ben’s favorite yerba mate and fiber: https://ufeelgreat.com/usa/en/c/1BA884 Exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code BEN10 for a 10% discount: https://cleanformnutrition.com/produc... Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15)