Differences between Heme Oxygenase and Biliverdin Reductase Enzymes ; Definition, Roles in Heme скачать в хорошем качестве

Differences between Heme Oxygenase and Biliverdin Reductase Enzymes ; Definition, Roles in Heme

Heme oxygenase and biliverdin reductase are both enzymes involved in the breakdown of heme, but they have distinct roles and functions: Heme Oxygenase Function: Catalyzes the first step in heme catabolism by breaking down heme into biliverdin, carbon monoxide (CO), and iron. Isozymes: There are two main isoforms, heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2). HO-1 is inducible and can be upregulated in response to stress, while HO-2 is constitutively expressed1. Products: Produces biliverdin, CO, and iron. Biliverdin Reductase Function: Catalyzes the second step in heme catabolism by converting biliverdin into bilirubin. Products: Produces bilirubin, which is then transported to the liver for further processing and excretion. Summary Heme Oxygenase: Breaks down heme into biliverdin, CO, and iron. Biliverdin Reductase: Converts biliverdin into bilirubin #HemeOxygenase #BiliverdinReductase