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In this week’s HeartBrief, Dr. Joel Kahn spotlights three practice-changing studies that reshape how clinicians assess cardiovascular risk. First, a massive two-cohort analysis reveals a powerful, newly recognized interaction between genetically inherited lipoprotein(a) and ABO blood type—showing that patients with elevated Lp(a) and non-O blood groups face significantly higher adverse event rates, a finding that may influence future prevention strategies. Next, he breaks down compelling ARIC data demonstrating that the American Heart Association’s Life’s Essential 8 remains one of the strongest long-term predictors of coronary heart disease, stroke, and atrial fibrillation—reinforcing its value as a simple, actionable tool for patient counseling. Finally, Dr. Kahn tackles widespread underuse of coronary artery calcium scoring, with new MESA results confirming that CAC dramatically improves ASCVD risk reclassification in low- and borderline-risk individuals—potentially altering who should start or defer statin therapy. Three studies, three opportunities to sharpen preventive cardiology in real-world care.