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In this episode of Your Checkup, we explore a new study from the Mayo Clinic examining whether menopause hormone therapy enhances weight loss outcomes in postmenopausal women taking tirzepatide. Menopause is a major metabolic turning point — with rising visceral fat, declining muscle mass, and increasing cardiovascular risk. Researchers found that women using hormone therapy while on tirzepatide lost significantly more weight — nearly 5% more total body weight — and experienced additional cardiometabolic improvements compared to women not using hormones. We break down what this means, why estrogen may play a synergistic role, what the study does not prove, and how to think about personalized obesity treatment during midlife. Send us a message with this link, we would love to hear from you. Standard message rates may apply. (https://www.buzzsprout.com/twilio/tex...) Support the show (https://buymeacoffee.com/yourcheckup) Production and Content: Edward Delesky, MD, DABOM & Nicole Aruffo, RN Artwork Rebrand and Avatars: Vantage Design Works (Vanessa Jones) Website: https://www.vantagedesignworks.com/ Instagram: https://www.instagram.com/vantagedesi... Original Artwork Concept: Olivia Pawlowski