Managing Infections after Transplant and CAR T-cell Therapy скачать в хорошем качестве

Managing Infections after Transplant and CAR T-cell Therapy

Summary: This presentation provides an overview of common infections seen after transplant or CAR-T therapy, outlines treatment options and explains steps both patients and physicians can take to reduce the risk of developing infections. Presenter: Gowri Satyanarayana MD Northside Hospital Cancer Institute https://providers.northside.com/provi... As presented at the 2025 Survivorship Symposium, May 3-9 Presentation is 33 minutes with 23 minutes of Q & A To read the transcript, go to: https://bmtinfonet.org/video/managing... Highlights: (02:58): A neutropenic fever is often the first sign of an infection in a patient who has undergone CAR-T therapy, an autologous transplant, or an allogeneic transplant. (06:47): Bacterial infections can occur at a variety of sites within the body. These infections can come from outside exposure to something, but more often come from the normal bacteria living inside of you, which get disrupted by chemotherapy or other medications given at the time of your transplant or CAR-T therapy. (14:00): Common fungal infections that we encounter after transplants are caused by yeasts and molds. Fungal infections are infrequent in CAR-T cell recipients. (17:58) Herpes simplex and varicella zoster (which causes shingles) are common viral infections that can occur after transplant and CAR-T therapy. These are usually viruses that the patient was exposed to in the past and have remained dormant in their body. (20:10): Cytomegalovirus (CMV) is another viral infection that patients can be exposed to before transplant or CAR T-cell therapy, that reactivates, or grows inside of you, after transplant or CAR T-cell therapy. CMV is quite rare after an autologous transplant (24:47): Norovirus, often referred to as the ‘cruise ship virus’ may infect the gastrointestinal tract after transplant or CAR T-cell therapy and cause chronic diarrhea that may continue for two to three weeks. (26:09): The main parasitic infection after transplant and CAR T-cell therapy is toxoplasma. (29:38): Infection prevention is important, and there are specific ways patients and caregivers can protect themselves. (30:59): Patients who want to travel outside of the US will generally need to be approval to travel from their care team (31:28): Vaccinations are given after transplant and CAR-T to protect against infection. Key Points: Infections after transplant or CAR-T therapy can be caused by bacteria, viruses, fungi or parasites. Transplant and CAR-T-cell patients usually receive prophylactic medications to reduce the risk of developing infections. Because the immune system is weakened by transplant or CAR-T therapy, it’s important that patients protect themselves against infection with frequent hand washing, masking, vaccinations, and limiting travel.  VISIT US ON SOCIAL MEDIA:   / bmtinfonet     / bonemarrowstemcelltransplantclub     / bmtinfonet   https://x.com/BMTInfoNet   / bmt-infonet   https://bsky.app/profile/bmtinfonet.b...