Non-Canonical NF-kB Signaling Pathway | Mechanism and Function скачать в хорошем качестве

Non-Canonical NF-kB Signaling Pathway | Mechanism and Function

Lesson on the Non-Canonical NF-kB Signaling pathway. The Noncanonical NFkB signaling pathway is primarily involved in B cell maturation, lymphoid organogenesis and immune system functioning. This signaling pathway differs from the canonical pathway in terms of cell receptors and cytosolic adaptor proteins. In a constitutional, inactivated state, cell levels of NIK are kept low due to proteasomal degradation. However, when this pathway becomes activated, NIK levels rise, leading to activation of IKKalpha and subsequent formation of an active protein dimer. This active protein dimer translocates into the nucleus and leads to the induction of non-canonical NF-kB signaling genes, which increase B cell survival. Unsurprisingly, mutations in this pathway can lead to the onset of specific immune cancers including Hodgkin’s lymphoma and diffuse large B cell lymphoma. **Re-uploaded to support 1080p video quality.** Hey everyone. Here is an introductory lesson on the Noncanonical NF-kB signaling pathway, its purpose, mechanism, function, which genes it induces and its involvement in certain immuno-pathologies. This video also marks the beginning of videos in 1080p high definition. I hope you find this video helpful. If you did, please like and subscribe for more videos :) JJ Subscribe for more free medical lessons    / @jjmedicine   ------------------------------------------------------------------------------------------------------------- For books and more information on these topics https://www.amazon.com/shop/jjmedicine Support future lessons (and get other cool stuff) ➜   / jjmedicine   Follow me on Twitter! ➜   / jj_medicine   Come join me on Facebook! ➜   / jj-medicine-100642648161192   Start your own website with BlueHost ➜ https://www.bluehost.com/track/jjmedi... Check out the best tool to help grow your YouTube channel (it’s helped me!) https://www.tubebuddy.com/jjmedicine ------------------------------------------------------------------------------------------------------------- Check out some of my other lessons. Medical Terminology - The Basics - Lesson 1:    • Medical Terminology - The Basics - Lesson 1   Fatty Acid Synthesis Pathway:    • Fatty Acid Synthesis Pathway: Overview, En...   Wnt/B Catenin Signaling Pathway:    • Wnt/β-Catenin Signaling Pathway | Overview...   Upper vs. Lower Motor Neuron Lesions:    • Upper and Lower Motor Neuron Lesions | UMN...   Lesson on the Purine Synthesis and Salvage Pathway:    • Purine Synthesis and Salvage Pathway   Gastrulation | Formation of Germ Layers:    • Gastrulation | Formation of Germ Layers | ...   Introductory lesson on Autophagy (Macroautophagy):    • Autophagy | Macroautophagy & Importance in...   Infectious Disease Playlist    • Infectious Diseases   Dermatology Playlist    • Dermatology   Pharmacology Playlist    • Pharmacology   Hematology Playlist    • Hematology   Rheumatology Playlist    • Rheumatology   Endocrinology Playlist    • Endocrinology   Nephrology Playlist    • Nephrology   ---------------------------------------------------------------------------------------------------- **MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal. Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition. ---------------------------------------------------------------------------------------------------- Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know. I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :) Thanks for watching! If you found this video helpful, please like and subscribe! JJ